Fig. 1. Role of adipose tissues for cardiometabolic homeostasis under healthy conditions.

Fig. 1

Role of adipose tissues for cardiometabolic homeostasis under healthy conditions. In metabolic health, white and brown adipose can control systemic lipid homeostasis by regulating both the efficient clearance of triglyceride-rich lipoproteins and the release of fatty acids under catabolic conditions. Healthy adipose tissues harbor mostly anti-inflammatory immune cells (indicated by blue-colored immune cells) that are important to maintain tissue homeostasis. Under this condition, adipocytes mostly release beneficial hormones such as anti-inflammatory lipokines, adiponectin, and FGF21 that support vascular health by direct effects on arteries or indirectly by regulating hepatic lipid metabolism. Overall, healthy adipose tissues are associated with a state of metabolic flexibility that prevents atherosclerosis. BAT brown adipose tissue, FFA free fatty acids, FGF21 fibroblast growth factor 21, LPL lipoprotein lipase, NRG4 neuregulin 4, PVAT perivascular adipose tissue, Rm remnants, TRL triglyceride-rich lipoproteins, WAT white adipose tissue

From: Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis

Cover of Prevention and Treatment of Atherosclerosis
Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets [Internet].
von Eckardstein A, Binder CJ, editors.
Cham (CH): Springer; 2022.
Copyright 2020, The Author(s)

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