Table 7Summary of the Stepped Analysis of the CADTH Reanalysis Results for Satralizumab as Monotherapy Versus No Treatment

Stepped analysisDrugTotal costs ($)Total LYsTotal QALYsICER ($/QALYs)
Sponsor’s base caseNo treatment827,34621.811.99Reference
Satralizumab2,180,77022.956.92274,700
Sponsor’s corrected base caseNo treatment821,78321.721.97Reference
Satralizumab2,089,92023.106.99252,635
CADTH reanalysis 1No treatment822,49021.791.98Reference
Satralizumab2,190,70922.926.09332,790
CADTH reanalysis 2No treatment811,17321.573.70Reference
Satralizumab2,163,28522.978.22298,838
CADTH base caseNo treatment824,87721.813.69Reference
Satralizumab2,112,85322.957.51337,535

ICER = incremental cost-effectiveness ratio; LY = life-year; QALY = quality-adjusted life-year.

a

Corrections are minor errors (e.g., transcription errors between report and model, misapplication of distributions or SEs in probabilistic analyses) that are not identified as limitations.

b

Reanalysis applied only in the sponsor’s base case for satralizumab combination therapy.

From: Economic Review

Cover of Pharmacoeconomic Report: Satralizumab (Enspryng)
Pharmacoeconomic Report: Satralizumab (Enspryng): (Hoffmann-La Roche Limited): Indication: Neuromyelitis optica spectrum disorder [Internet].
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