Key Points
  • If the Geenius HIV 1/2 Supplemental Assay interpretation is nonreactive or indeterminate for any HIV type (HIV-1, HIV-2, or untypable HIV), test the specimens for HIV-1 RNA, even if the result is HIV-2 indeterminate.
  • Nonspecific reactivity could cause an HIV-2 indeterminate result to occur in some cases.
  • If HIV-1 RNA is not detected and the Geenius Reader interpretation is HIV-2 indeterminate or HIV indeterminate, an HIV-2 NAT may be warranted.

From: HIV Testing

Cover of HIV Testing
HIV Testing [Internet].
Tsoi BW, Parker M, Fine SM, et al.
Baltimore (MD): Johns Hopkins University; 2022 May.
Copyright © Johns Hopkins University Clinical Guidelines Program 2000-2024. The Clinical Guidelines Program, a collaborative effort of the NYSDOH AI and the Johns Hopkins University School of Medicine, Division of Infectious Diseases, encourages the use, reproduction, and distribution of original documents and related graphics from this program website accompanied by a full citation of source that includes: Author(s). Committee. Title. Date of publication. Full URL. Date accessed. Links to pages on this Clinical Guidelines Program website are also encouraged and may be created without seeking permission. Requests to adapt material, i.e., to change or alter in any way material from this website for inclusion in another publication, should be sent to aiguidelines@jhmi.edu. Please include detailed information about the intended use and desired adaptations.

This book is licensed under the terms of the Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0).

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.