Table 6Evidence examining the relationship between shorter versus longer durations of any human milk feeding and asthma in adulthood1

Author and year

Study design (cohort name when applicable)

Country

Notable sample characteristicsShorter versus longer duration of any human milk feeding exposure2Significant associations with asthmaNonsignificant associations with asthma

Grabenhenrich 2014 (28)

Prospective cohort (MAS)

Germany

N=941

Baseline: Birth

Race/ethnicity NR

Risk: “Risk enriched” 38% family history (≥2 first degree relatives)

BF ≥6 mo vs BF <6 moNoneAsthma by age 20 y: HR 0.92 (95% CI: 0.70, 1.22)

da Costa Lima 2003 (27)

Prospective cohort (Pelotas Birth Cohort Study)

Brazil

N=2,247

Baseline: Birth

100% male

Race/ethnicity NR

BF ≥9 mo vs BF <3 moAsthma at 18 y: 42% more likely (95% CI: 13%, 77%)None
1

Abbreviations: BF - breastfeeding, CI - confidence interval, HR – hazard ratio, MAS - Multicenter Allergy Study, mo - months, NR - not reported, y - years

2

Exposures, as defined by the authors of the studies included in the body of evidence, which address shorter versus longer durations of any human milk feeding or vice versa

From: WHAT IS THE RELATIONSHIP BETWEEN SHORTER VERSUS LONGER DURATIONS OF ANY HUMAN MILK FEEDING AND FOOD ALLERGIES, ALLERGIC RHINITIS, ATOPIC DERMATITIS, AND ASTHMA?

Cover of Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review
Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review [Internet].
Güngör D, Nadaud P, Dreibelbis C, et al.
Alexandria (VA): USDA Nutrition Evidence Systematic Review; 2019 Apr.
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