Table 1Evidence examining the relationship between shorter versus longer durations of any human milk feeding and food allergies1

Article

Study design (cohort name)

Country

Notable sample characteristicsShorter versus longer duration of any human milk feeding exposures2Significant associations with food allergiesNonsignificant associations with food allergies

Grimshaw 2013 (1)

Nested case-control (PIFA)

UK

N=41 cases with food allergy by 2 y, 82 controls

Baseline: Birth

Race/ethnicity NR

Median BF duration in cases with food allergy by 2 y vs controlsNone21.0 wk (IQR: 3.0, 30.5) vs 24.0 wk (IQR: 7.0, 31.0), p=0.295

Hesselmar 2010 (2)

Prospective cohort (ALLERGYFLORA)

Sweden

N=184

Baseline: 1-3 d

Race/ethnicity NR

Risk: 80% family history (≥1 parent)

Median duration of partial BF in participants with and without food allergy by 18 moNone8.5 mo (IQR: 5.5, 10.1) vs 7 mo (IQR: 4.5, 9.0), p=0.248

Poole 2006 (3)

Prospective cohort (DAISY)

US

N=1,612

Baseline: Birth

Race/ethnicity:

70% Non-Hispanic White

23% Hispanic

3.6% Biracial

2.2% Black

0.74% Other/Missing

Risk: 100% high-risk for T1D (genotype/family history)

BF duration, per 1-mo increaseWheat allergy by 4 y: OR 1.05 (95% CI: 1.00, 1.11)3None
1

ALLERGYFLORA = Impact Of Intestinal Microflora On Allergy Development; BF = Breastfeeding; CI = Confidence Interval; D = Days; DAISY = Diabetes Autoimmunity Study In The Young; IQR = Interquartile Range; Mo = Months; NR = Not Reported; OR = Odds Ratio; PIFA = Prevalence Of Infant Food Allergy Study; T1D = Type 1 Diabetes; Wk = Weeks; Y = Years

2

Exposures, as defined by the authors of the studies included in the body of evidence, which address shorter versus longer durations of any human milk feeding or vice versa

3

The CI includes the null however the authors describe the association as significant

From: WHAT IS THE RELATIONSHIP BETWEEN SHORTER VERSUS LONGER DURATIONS OF ANY HUMAN MILK FEEDING AND FOOD ALLERGIES, ALLERGIC RHINITIS, ATOPIC DERMATITIS, AND ASTHMA?

Cover of Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review
Shorter Versus Longer Durations of Any Human Milk Feeding and Food Allergies, Allergic Rhinitis, Atopic Dermatitis, and Asthma: A Systematic Review [Internet].
Güngör D, Nadaud P, Dreibelbis C, et al.
Alexandria (VA): USDA Nutrition Evidence Systematic Review; 2019 Apr.
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