Table 18Incidences of Select Nonneoplastic Lesions of the Nose in Female B6C3F1/N Mice in the Three-month Gavage Study of Trans-resveratrol

0 mg/kg/day156 mg/kg/day312 mg/kg/day625 mg/kg/day1,250 mg/kg/day2,500 mg/kg/day
na 101010101010
Olfactory Epithelium, Metaplasia, Respiratoryb0**002 (1.0)c2 (1.0)4* (1.0)

Statistical significance for a dose group indicates a significant pairwise test compared to the vehicle control group. Statistical significance for the vehicle control group indicates a significant trend test.

*

Statistically significant at p ≤ 0.05 by the Cochran-Armitage (trend) or Fisher’s exact (pairwise) tests; **p ≤ 0.01.

a

Number of animals examined microscopically.

b

Number of animals with lesion.

c

Average severity grade of observed lesion in affected animals: 1 = minimal; 2 = mild; 3 = moderate; 4 = marked.

From: Results

Cover of NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice
NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice: Toxicity Report 102 [Internet].
National Toxicology Program.
Research Triangle Park (NC): National Toxicology Program; 2021 Dec.
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