Table 5Summary of Mean Litter Size and Survival Ratio of F1 Male and Female Wistar Han Rats during Lactation in the Perinatal and Three-month Gavage Study of Trans-resveratrol

Parameter0 mg/kg/day78 mg/kg/day156 mg/kg/day312.5 mg/kg/day625 mg/kg/day1,250 mg/kg/day
PND 1
Totala,b8.58 ± 0.56
(19)		8.91 ± 0.50
(22)		8.00 ± 0.78
(13)		7.53 ± 0.76
(19)		7.64 ± 0.99
(11)		8.67 ± 0.54
(18)
Livea,b8.58 ± 0.56
(19)		8.86 ± 0.49
(22)		8.00 ± 0.78
(13)		7.53 ± 0.76
(19)		7.64 ± 0.99
(11)		8.67 ± 0.54
(18)
% Malec,d51.0 (149)53.0 (185)56.4 (94)54.5 (143)52.4 (84)58.0 (150)
% Male/Littera,b51.3 ± 2.9
(18)		53.0 ± 5.2
(21)		58.4 ± 6.0
(12)		54.4 ± 4.9
(19)		43.4 ± 7.5
(11)		59.6 ± 4.5
(17)
Malea,b
PND 14.22 ± 0.37
(18)		4.67 ± 0.52
(21)		4.42 ± 0.62
(12)		4.11 ± 0.57
(19)		4.00 ± 0.76
(11)		5.12 ± 0.44
(17)
PND 4 Prestandardization4.17 ± 0.35
(18)		4.67 ± 0.52
(21)		4.42 ± 0.62
(12)		4.05 ± 0.55
(19)		4.00 ± 0.76
(11)		5.06 ± 0.46
(17)
PND 4 Poststandardization4.00 ± 0.00
(7)		4.00 ± 0.00
(7)		4.00 ± 0.22
(7)		4.14 ± 0.14
(7)		4.14 ± 0.14
(7)		4.00 ± 0.22
(7)
Femalea,b
PND 14.06 ± 0.36
(18)		4.14 ± 0.48
(21)		3.42 ± 0.57
(12)		3.42 ± 0.45
(19)		3.64 ± 0.36
(11)		3.71 ± 0.53
(17)
PND 4 Prestandardization4.06 ± 0.36
(18)		4.14 ± 0.48
(21)		3.42 ± 0.57
(12)		3.37 ± 0.46
(19)		3.64 ± 0.36
(11)		3.71 ± 0.53
(17)
PND 4 Poststandardization4.00 ± 0.00
(7)		4.00 ± 0.00
(7)		4.00 ± 0.22
(7)		3.86 ± 0.14
(7)		3.86 ± 0.14
(7)		4.00 ± 0.22
(7)
Male and Femalea,b
PND 4 Prestandardization8.53 ± 0.56
(19)		8.86 ± 0.49
(22)		8.00 ± 0.78
(13)		7.42 ± 0.77
(19)		7.64 ± 0.99
(11)		8.61 ± 0.53
(18)
PND 4 Poststandardization8.00 ± 0.00
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)
PND 218.00 ± 0.00
(7)		8.00 ± 0.00
(7)		7.86 ± 0.14
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)		8.00 ± 0.00
(7)
Survival/Litter
Total Dead: PND 1–4d,e1 (1)1 (1)0 (0)2 (2)0 (0)1 (1)
Total Dead: PND 4–21d,e0 (0)0 (0)1 (1)0 (0)0 (0)0 (0)
Dead: PND 1–4a,b,f0.05 ± 0.05
(19)		0.05 ± 0.05
(22)		0.00 ± 0.00
(13)		0.11 ± 0.07
(19)		0.00 ± 0.00
(11)		0.06 ± 0.06
(18)
Dead: PND 4–21a,b,f0.00 ± 0.00
(7)		0.00 ± 0.00
(7)		0.14 ± 0.14
(7)		0.00 ± 0.00
(7)		0.00 ± 0.00
(7)		0.00 ± 0.00
(7)
Survival Ratio: PND 1–4a,b,g1.00 ± 0.01
(19)		1.00 ± 0.00
(22)		1.00 ± 0.00
(13)		0.98 ± 0.01
(19)		1.00 ± 0.00
(11)		0.99 ± 0.01
(18)
Survival Ratio: PND 4–21a,b,h1.00 ± 0.00
(7)		1.00 ± 0.00
(7)		0.98 ± 0.02
(7)		1.00 ± 0.00
(7)		1.00 ± 0.00
(7)		1.00 ± 0.00
(7)

PND = postnatal day.

a

Each dose group was compared to the vehicle control group with the Shirley test when a trend was present (p ≤ 0.01 from the Jonckheere trend test) or with the Dunn test when no trend was present.

b

Data are presented as mean ± standard error (number of litters).

c

100 × [number of live males in dose group]/[number of live males and females in dose group] (number of pups).

d

No statistical analysis performed on this endpoint.

e

Total number of dead pups in dose group (number of litters with dead pups).

f

Number dead/litter (number of litters).

g

Survival/litter: Number of live pups on PND 4/number of live pups on PND 1.

h

Survival/litter: Number of live pups on PND 21/number of live pups poststandardization on PND 4.

From: Results

Cover of NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice
NTP Technical Report on the Toxicity Studies of Trans-resveratrol (CASRN 501-36-0) Administered by Gavage for Two Weeks or Three Months to F344/NTac Rats, Wistar Han [Crl:WI(Han)] Rats, and B6C3F1/N Mice: Toxicity Report 102 [Internet].
National Toxicology Program.
Research Triangle Park (NC): National Toxicology Program; 2021 Dec.
Copyright Notice

This is a work of the US government and distributed under the terms of the Public Domain

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.