| 1. | exp Hypertension/ |
| 2. | hypertens*.ti,ab. |
| 3. | (elevat* adj2 blood adj pressur*).ti,ab. |
| 4. | (high adj blood adj pressur*).ti,ab. |
| 5. | (increase* adj2 blood pressur*).ti,ab. |
| 6. | ((systolic or diastolic or arterial) adj2 pressur*).ti,ab. |
| 7. | or/1–6 |
| 8. | exp pregnancy/ |
| 9. | exp Maternal Hypertension/ |
| 10. | (pre eclampsia or pre-eclampsia or preeclampsia).ti,ab. |
| 11. | exp Hypertension, Portal/ not exp Hypertension/ |
| 12. | exp Hypertension, Pulmonary/ not exp Hypertension/ |
| 13. | exp Intracranial Hypertension/ |
| 14. | exp Ocular Hypertension/ not exp Hypertension/ |
| 15. | exp Diabetes Mellitus, Type 1/ not exp Diabetes Mellitus, Type 2/ |
| 16. | or/8–15 |
| 17. | 7 not 16 |
| 18. | letter.pt. or letter/ |
| 19. | note.pt. |
| 20. | editorial.pt. |
| 21. | case report/ or case study/ |
| 22. | (letter or comment*).ti. |
| 23. | or/18–22 |
| 24. | randomized controlled trial/ or random*.ti,ab. |
| 25. | 23 not 24 |
| 26. | animal/ not human/ |
| 27. | nonhuman/ |
| 28. | exp Animal Experiment/ |
| 29. | exp Experimental Animal/ |
| 30. | animal model/ |
| 31. | exp Rodent/ |
| 32. | (rat or rats or mouse or mice).ti. |
| 33. | or/25–32 |
| 34. | 17 not 33 |
| 35. | (exp child/ or exp pediatrics/) not (exp adult/ or exp adolescent/) |
| 36. | 34 not 35 |
| 37. | limit 36 to English language |
| 38. | exp *Angiotensin-Converting Enzyme Inhibitors/ |
| 39. | Angiotensin-converting enzyme inhibitor*.ti,ab. |
| 40. | (ACE inhibitor* or ACEI).ti,ab. |
| 41. | (Captopril or Enalapril or Fosinopril or Imidapril or Lisinopril or Moexipril or Perindopril or Quinapril or Ramipril or Trandolapril or Capoten or Ecopace or Noyada or Innovace or Tanatril or Zestril or Perdix or Coversil or Accupro or Tritace).ti,ab. |
| 42. | *Captopril/ or *Enalapril/ or *Fosinopril/ or *Imidapril/ or *Lisinopril/ or *Moexipril/ or *Perindopril/ or *Quinapril/ or *Ramipril/ or *Trandolapril/ or *enalapril maleate/ |
| 43. | *angiotensin receptor antagonist/ |
| 44. | (Angiotensin II adj3 (antagonist* or blocker*)).ti,ab. |
| 45. | ARB.ti,ab. |
| 46. | (Azilsartan or Candesartan or Eprosartan or Irbesartan or Losartan or Olmesartan or Telmisartan or Valsartan or Edarbi or Amias or Teveten or Aprovel or Ifirmasta or Sabervel or Cozaar or Olmetec or Tolura or Micardis or Diovan).ti,ab. |
| 47. | *Azilsartan/ or *Candesartan/ or *Eprosartan/ or *Irbesartan/ or *Losartan/ or *Valsartan/ or *Olmesartan Medoxomil/ or *Telmisartan/ |
| 48. | exp *Calcium Channel Blockers/ |
| 49. | Calcium channel blocker*.ti,ab. |
| 50. | CCB.ti,ab. |
| 51. | (Amlodipine or Clevidipine or Diltiazem or Felodipine or Isradipine or Lacidipine or Lercanidipine or Nicardipine or Nifedipine or Verapamil or Amlostin or Istin or Adizem or Angitil or Dilcardia or Dilzem or Slozem or Tildiem or Viazem or Zemtard or Kenzem or Cardioplen or Felendil or Neofel or Parmid or Plendil or Pinefeld or Vascalpha or Molap or Motens or Zanidip or Cardene or Adalat or Adipine or Coracten or Fortipine or Nifedipress or Tensipine or Valni or Securon or Verapress or Vertab or Univer or Zolvera or Cleviprex).ti,ab. |
| 52. | *Amlodipine/ or *Diltiazem/ or *Felodipine/ or *Isradipine/ or *Nicardipine/ or *Nifedipine/ or *Verapamil/ |
| 53. | *Diuretics/ |
| 54. | *thiazide diuretic agent/ |
| 55. | ((thiazide or thiazide-like or non-thiazide or conventional or potassium sparing) adj3 diuretic*).ti,ab. |
| 56. | *mineralocorticoid antagonist/ |
| 57. | ((mineralocorticoid or aldosterone) adj3 antagonist*).ti,ab. |
| 58. | (Amiloride or Cyclopenthiazide or Spironolactone or Eplerenone or Bendroflumethiazide or Hydrochlorothiazide or Co-amilozide or Co-triamterzide or Co-zidocapt or Chlortalidone or Indapamide or Metolazone or Xipamide or Carace or Zestoretic or Coversyl or Accuretic or Cozaar or Sevikar or Olmetec or Actelsar or Tolucombi or Co-Diovan or Hygroton or Co-tenidone or Kalspare or Natrilix or Cardide or Indipam or Rawel or Tensaid or Alkapamid or Zaroxolyn or Diurexan or Aprinox or Neo-Naclex or CoAprovel or Lisoretic or Dyazide or Navispare or Lasilactone).ti,ab. |
| 59. | *Amiloride/ or *Cyclopenthiazide/ or *Spironolactone/ or *Bendroflumethiazide/ or *Hydrochlorothiazide/ or *Chlortalidone/ or *Indapamide/ or *Metolazone/ or *Xipamide/ |
| 60. | *Adrenergic beta-Antagonists/ |
| 61. | (adrenergic beta antagonist* or beta blocker* or b blocker*).ti,ab. |
| 62. | (Carvedilol or Labetalol or Atenolol or Nadolol or Oxprenolol or Pindolol or Propranolol or Timolol or Acebutolol or Bisoprolol or Celiprolol or Esmolol or Metoprolol or Nebivolol or Carvedilol or Tenormin or Tenif or Corgard or Slow-Trasicor or Visken or Viskladix or Bedranol or Beta-Prograne or Syprol or Betim or Sectral or Cardicor or Congescor or Celectol or Breviblock or Betaloc or Lopresor or Nebilet).ti,ab. |
| 63. | *Carvedilol/ or *Labetalol/ or *Nadolol/ or *Oxprenolol/ or *Pindolol/ or *Propranolol/ or *Timolol/ or *Acebutolol/ or *Bisoprolol/ or *Celiprolol/ or *Metoprolol/ or *Nebivolol/ |
| 64. | exp *Adrenergic alpha-Antagonists/ |
| 65. | (adrenergic alpha antagonist* or alpha adrenoreceptor blocker* or alpha blocker*).ti,ab. |
| 66. | (Doxazosin or Prazosin or Terazosin or Cardura or Doxadura or Raporsin or Slocinx or Doxzogen or Larbex or Hypovase or Hytrin).ti,ab. |
| 67. | *doxazosin/ or *Prazosin/ or *Terazosin/ |
| 68. | *Antihypertensive Agents/ |
| 69. | centrally acting antihypertensive*.ti,ab. |
| 70. | (Clonidine or Moxonidine or Methyldopa or Catapres or Dixarit or Aldomet or Physiotens).ti,ab. |
| 71. | *clonidine/ or *moxonidine/ or *Methyldopa/ |
| 72. | renin inhibitor*.ti,ab. |
| 73. | (Aliskiren or Rasilez).ti,ab. |
| 74. | *Aliskiren/ |
| 75. | or/38–74 |
| 76. | 37 and 75 |
| 77. | random*.ti,ab. |
| 78. | factorial*.ti,ab. |
| 79. | (crossover* or cross over*).ti,ab. |
| 80. | ((doubl* or singl*) adj blind*).ti,ab. |
| 81. | (assign* or allocat* or volunteer* or placebo*).ti,ab. |
| 82. | crossover procedure/ |
| 83. | single blind procedure/ |
| 84. | randomized controlled trial/ |
| 85. | double blind procedure/ |
| 86. | or/77–85 |
| 87. | systematic review/ |
| 88. | meta-analysis/ |
| 89. | (meta analy* or metanaly* or metaanaly* or meta regression).ti,ab. |
| 90. | ((systematic* or evidence*) adj3 (review* or overview*)).ti,ab. |
| 91. | (reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab. |
| 92. | (search strategy or search criteria or systematic search or study selection or data extraction).ab. |
| 93. | (search* adj4 literature).ab. |
| 94. | (medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or science citation index or bids or cancerlit).ab. |
| 95. | cochrane.jw. |
| 96. | ((multiple treatment* or indirect or mixed) adj2 comparison*).ti,ab. |
| 97. | or/87–96 |
| 98. | 76 and (86 or 97) |
From: Evidence review for step 4 treatment
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.