Table 1Summary of Dose Groups for Mice Treated with AZT

Treatment GroupDaily Dose
0/0 or 0/0/0 mg/kg240/40 mg/kg80/40/80 mg/kg160/80/160 mg/kg240/120/240 mg/kg
30-Week Studya
Dams or litters34b———36b
Males27———26
Females27———26
45-Week Studya
Dams or litters34b—181636b
Males27—272727
Females26—272727
45-Week Stop-Studyc
Dams or litters1214———
Males2425———
Females2626———
a

Pups in the 30- and 45-week studies were administered AZT doses that were half that of the maternal dose on PNDs 1 through 10. Pup doses were then doubled and animals received that dose from PND 11 until the end of the studies.

b

Pups from the same litters were assigned to either the 30-week study or the 45-week study.

c

For the 45-week stop-study, pups were exposed to 240 mg/kg in utero on GDs 12 through 18, then to 40 mg/kg on PNDs 1 through 8.

From: MATERIALS AND METHODS

Cover of NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study)
NTP Genetically Modified Model Report on the Toxicology and Carcinogenicity Studies of 3’-Azido-3’-Deoxythymidine (CASRN 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study): NTP GMM 14 [Internet].
Leakey JEA, Allaben WT, Dunnick JK, et al.
Research Triangle Park (NC): National Toxicology Program; 2013 Oct.
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