Table 1. [Endocrine disruptors affecting different endocrine organs]. - Endotext

Endocrine system	Endocrine disruptor chemical	Impact
Pituitary	Phytoestrogens (i.e., isoflavonoids, cumestans, lignans, stilbens); pesticides (i.e., organophosphates, carbamates, organochlorines, synthetic pyrethroids); Polyvinyl chloride (PVC); phenols, dioxins, heavy metals, perfluorooctanoic acid.	Precocious puberty, delayed puberty, disruption of the circadian rhythm
Adrenal	Xenoestrogens, Hexachlorobenzene	Adrenal biosynthetic defects
Thyroid	Perchlorate, thiocyanates, nitrates	Hypothyroidism
Gonads	Phthalates, vinclozolin, acetaminophen, and polybrominated diphenyl ethers (PBDE) Phthalates, diethylstilbestrol, bisphenol A (BPA) PCB, phtalates, atrazine, genistein, BPA, parabens, triclosan, dichlorodiphenyltrichloroethane (DDT), and metoxychloride (MXC) Phthalates, bisphenol A, biphenyls, and vinclozolin,	Testicular dysgenesis syndrome Endometriosis Female infertility Male infertility
Endocrine gland cancer	PDBE, organochlorides, PCB, DDT, dichlorodiphenyldichloroethylene (DDE), arsenic, and cadmium Triclocarban, PCB PCB, dioxins, cadmium, phytoestrogens, DES, furans, ethylene oxide	Testicular Cancer Thyroid Cancer Breast Cancer

Endocrine system

Endocrine disruptor chemical

Impact

Pituitary

Phytoestrogens (i.e., isoflavonoids, cumestans, lignans, stilbens); pesticides (i.e., organophosphates, carbamates, organochlorines, synthetic pyrethroids); Polyvinyl chloride (PVC); phenols, dioxins, heavy metals, perfluorooctanoic acid.

Precocious puberty, delayed puberty, disruption of the circadian rhythm

Adrenal

Xenoestrogens, Hexachlorobenzene

Adrenal biosynthetic defects

Thyroid

Perchlorate, thiocyanates, nitrates

Hypothyroidism

Gonads

Phthalates, vinclozolin, acetaminophen, and polybrominated diphenyl ethers (PBDE)
Phthalates, diethylstilbestrol, bisphenol A (BPA)
PCB, phtalates, atrazine, genistein, BPA, parabens, triclosan, dichlorodiphenyltrichloroethane (DDT), and metoxychloride (MXC)
Phthalates, bisphenol A, biphenyls, and vinclozolin,

Testicular dysgenesis syndrome
Endometriosis
Female infertility
Male infertility

Endocrine gland cancer

PDBE, organochlorides, PCB, DDT, dichlorodiphenyldichloroethylene (DDE), arsenic, and cadmium
Triclocarban, PCB
PCB, dioxins, cadmium, phytoestrogens, DES, furans, ethylene oxide

Testicular Cancer
Thyroid Cancer
Breast Cancer

From: Environmental Endocrinology: An Expanding Horizon

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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