Cost Comparison

Appendix 1Cost Comparison

The comparators presented in Table 5 have been deemed appropriate by clinical experts. Comparators may be recommended (appropriate) practice, rather than actual practice. Comparators are not restricted to drugs but may be devices or procedures. Costs are the sponsor’s list prices, unless otherwise specified. Existing Product Listing Agreements are not reflected in the table; as a result, the table may not represent the actual costs to public drug plans.

Table 5

CDR Cost Comparison Table for Treatments Indicated for the Treatment of Hypertriglyceridemia.

Table 6

CDR Cost-Comparison Table for Statins.

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Publisher

Canadian Agency for Drugs and Technologies in Health, Ottawa (ON)

NLM Citation

Pharmacoeconomic Review Report: Icosapent Ethyl (Vascepa): (HLS Therapeutics Inc.): Indication: Prevention of cardiovascular events in statin-treated patients [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Aug. Appendix 1, Cost Comparison.

Table 5CDR Cost Comparison Table for Treatments Indicated for the Treatment of Hypertriglyceridemia

Drug/ comparator	Strength	Dosage form	Price ($)	Recommended dosage	Average daily drug cost ($)	Average annual drug cost ($)
Submitted drug
Icosapent ethyl (Vascepa)	1 g	Capsule	2.4500^a	2 g twice daily	9.80	3,577
Cholesterol absorption inhibitor
Ezetimibe (Ezetrol)	10 mg	Tablet	0.1811	10 mg daily	0.18	66
Fibrates
Bezafibrate (Bezalip and generics)	400 mg	Tablet	1.7460	400 mg every morning or at bedtime	1.75	637
Fenofibrate (Lipidil and generics)	100 mg	Capsule	0.6105	3–4 caps divided three times daily before meals	1.83 to 2.4	669 to 891
Fenofibrate (Lipidil Micro and generics)	67 mg 200 mg	Capsule	0.5479 0.2723	67 to 200 mg daily	0.27 to 0.58	99 to 200
Fenofibrate (Lipidil EZ)	48 mg 145 mg	Tablet	0.3560 0.5489	48 to 145 mg daily	0.36 to 0.55	130 to 200
Gemfibrozil (Lopid and generics)	300 mg	Capsule	0.1340	600 mg twice daily after food	0.27	49
Micro-coated fenofibrate (Lipidil Supra and generics)	160 mg	Tablet	0.3116	160 mg daily	0.31	114
Niacin products
Niacin extended-release (Niaspan FCT)	500 mg 1,000 mg	Tablet	1.3600 1.4400	1,000 to 2,000 mg daily	1.44 to 2.88	523 to 1,051

a: Sponsor-submitted price.

: Note: All prices are from the Ontario Drug Benefit Formulary (accessed July 2019) unless otherwise indicated and do not include dispensing fees. Clinical expert feedback indicated fish oil products containing EPA, with or without DHA, may also be used in practice. Such products are not listed on formularies in Canada and are available over the counter.

Table 6CDR Cost-Comparison Table for Statins

Drug/ comparator	Strength	Dosage form	Price ($)	Recommended dosage	Average daily drug cost ($)	Average annual drug cost ($)
HMG-CoA reductase inhibitors (statins)
Atorvastatin (Lipitor and generics)	10 mg 20 mg 40 mg 80 mg	Tablet	0.1734 0.2179 0.2342 0.2342	10 mg to 80 mg at bedtime	0.17 to 0.23	63 to 85
Fluvastatin sodium (Lescol and generics)	20 mg 40 mg	Capsule	0.2202 0.3092	20 mg to 40 mg at bedtime	0.22 to 0.31	80 to 113
Fluvastatin sodium (Lescol XL)	80 mg	Tablet	1.6225	80 mg daily	1.62	592
Lovastatin (Mevacor and generics)	20 mg 40 mg	Tablet	0.4919 0.8985	20 mg to 80 mg at bedtime	0.49 to 1.80	180 to 656
Pravastatin sodium (Pravachol and generics)	10 mg 20 mg 40 mg	Tablet	0.2916 0.3440 0.4143	10 mg to 40 mg at bedtime	0.29 to 0.41	106 to 151
Rosuvastatin calcium (Crestor and generics)	5 mg 10 mg 20 mg 40 mg	Tablet	0.1284 0.1354 0.1692 0.1990	10 mg to 40 mg daily	0.14 to 0.20	49 to 73
Simvastatin (Zocor and generics)	5 mg 10 mg 20 mg 40 mg 80 mg	Tablet	0.1023 0.2023 0.2501 0.2501 0.2501	10 mg to 80 mg at bedtime	0.20 to 0.25	74 to 91

: HMG = beta-hydroxy beta-methylglutaryl.

: Note: All prices are from the Ontario Drug Benefit Formulary (accessed July 2019) unless otherwise indicated and do not include dispensing fees.