The comparators presented in have been deemed appropriate by clinical experts. Comparators may be recommended (appropriate) practice, rather than actual practice. Comparators are not restricted to drugs but may be devices or procedures. Costs are the sponsor’s list prices, unless otherwise specified. Existing Product Listing Agreements are not reflected in the table; as a result, the table may not represent the actual costs to public drug plans.
Table 5CDR Cost Comparison Table for Treatments Indicated for the Treatment of Hypertriglyceridemia
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| Drug/ comparator | Strength | Dosage form | Price ($) | Recommended dosage | Average daily drug cost ($) | Average annual drug cost ($) |
|---|
| Submitted drug |
|---|
| Icosapent ethyl (Vascepa) | 1 g | Capsule | 2.4500a | 2 g twice daily | 9.80 | 3,577 |
| Cholesterol absorption inhibitor |
|---|
| Ezetimibe (Ezetrol) | 10 mg | Tablet | 0.1811 | 10 mg daily | 0.18 | 66 |
| Fibrates |
|---|
| Bezafibrate (Bezalip and generics) | 400 mg | Tablet | 1.7460 | 400 mg every morning or at bedtime | 1.75 | 637 |
| Fenofibrate (Lipidil and generics) | 100 mg | Capsule | 0.6105 | 3–4 caps divided three times daily before meals | 1.83 to 2.4 | 669 to 891 |
| Fenofibrate (Lipidil Micro and generics) | 67 mg 200 mg | Capsule | 0.5479 0.2723 | 67 to 200 mg daily | 0.27 to 0.58 | 99 to 200 |
| Fenofibrate (Lipidil EZ) | 48 mg 145 mg | Tablet | 0.3560 0.5489 | 48 to 145 mg daily | 0.36 to 0.55 | 130 to 200 |
| Gemfibrozil (Lopid and generics) | 300 mg | Capsule | 0.1340 | 600 mg twice daily after food | 0.27 | 49 |
| Micro-coated fenofibrate (Lipidil Supra and generics) | 160 mg | Tablet | 0.3116 | 160 mg daily | 0.31 | 114 |
| Niacin products |
|---|
| Niacin extended-release (Niaspan FCT) | 500 mg 1,000 mg | Tablet | 1.3600 1.4400 | 1,000 to 2,000 mg daily | 1.44 to 2.88 | 523 to 1,051 |
- a
Note: All prices are from the Ontario Drug Benefit Formulary (accessed July 2019) unless otherwise indicated and do not include dispensing fees. Clinical expert feedback indicated fish oil products containing EPA, with or without DHA, may also be used in practice. Such products are not listed on formularies in Canada and are available over the counter.
Table 6CDR Cost-Comparison Table for Statins
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| Drug/ comparator | Strength | Dosage form | Price ($) | Recommended dosage | Average daily drug cost ($) | Average annual drug cost ($) |
|---|
| HMG-CoA reductase inhibitors (statins) |
|---|
| Atorvastatin (Lipitor and generics) | 10 mg 20 mg 40 mg 80 mg | Tablet | 0.1734 0.2179 0.2342 0.2342 | 10 mg to 80 mg at bedtime | 0.17 to 0.23 | 63 to 85 |
| Fluvastatin sodium (Lescol and generics) | 20 mg 40 mg | Capsule | 0.2202 0.3092 | 20 mg to 40 mg at bedtime | 0.22 to 0.31 | 80 to 113 |
| Fluvastatin sodium (Lescol XL) | 80 mg | Tablet | 1.6225 | 80 mg daily | 1.62 | 592 |
| Lovastatin (Mevacor and generics) | 20 mg 40 mg | Tablet | 0.4919 0.8985 | 20 mg to 80 mg at bedtime | 0.49 to 1.80 | 180 to 656 |
| Pravastatin sodium (Pravachol and generics) | 10 mg 20 mg 40 mg | Tablet | 0.2916 0.3440 0.4143 | 10 mg to 40 mg at bedtime | 0.29 to 0.41 | 106 to 151 |
| Rosuvastatin calcium (Crestor and generics) | 5 mg 10 mg 20 mg 40 mg | Tablet | 0.1284 0.1354 0.1692 0.1990 | 10 mg to 40 mg daily | 0.14 to 0.20 | 49 to 73 |
| Simvastatin (Zocor and generics) | 5 mg 10 mg 20 mg 40 mg 80 mg | Tablet | 0.1023 0.2023 0.2501 0.2501 0.2501 | 10 mg to 80 mg at bedtime | 0.20 to 0.25 | 74 to 91 |
HMG = beta-hydroxy beta-methylglutaryl.
Note: All prices are from the Ontario Drug Benefit Formulary (accessed July 2019) unless otherwise indicated and do not include dispensing fees.