Table 2: Preferred Regimens for HCV Treatment-Naive Patients
Genotype Regimen Treatment Duration
No CirrhosisCompensated Cirrhosis
1a, 1b, 2, 4, 5, 6Glecaprevir 300 mg/pibrentasvir 120 mg once daily8 weeks [a]8 weeks [b]
Sofosbuvir 400 mg/velpatasvir 100 mg once daily12 weeks [c]12 weeks [c]
3Glecaprevir 300 mg/pibrentasvir 120 mg once daily12 weeks [d]12 weeks [e]
Sofosbuvir 400 mg/velpatasvir 100 mg once daily12 weeks [f]12 weeks [g,h]

Abbreviations: HCV, hepatitis C virus; RAS, resistance-associated substitution; RBV, ribavirin.

Notes:

a
b
c
d
e
f
g
h

Patients with genotype 3 and compensated cirrhosis require baseline NS5A RAS testing. Those without Y93H can be treated with 12 weeks of sofosbuvir/velpatasvir, and those with the Y93H RAS can be treated with sofosbuvir/velpatasvir plus weight-based RBV [Esteban, et al. 2018].

From: Treatment of Chronic Hepatitis C Virus Infection in Adults

Cover of Treatment of Chronic Hepatitis C Virus Infection in Adults
Treatment of Chronic Hepatitis C Virus Infection in Adults [Internet].
Bernstein DE, Aron JS, Kerr CA, et al.
Baltimore (MD): Johns Hopkins University; 2023 Apr.
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