U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

Cover of LiverTox

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Show details

Liver Biopsy

Last Update: November 20, 2019.

Liver biopsy can be helpful in the assessment of suspected drug induced liver disease, but is usually not necessary unless an important therapeutic or diagnostic decision rests upon rapid establishment of the diagnosis. Thus, liver biopsy can be helpful in assessing acute onset of liver disease after bone marrow transplantation, so as to distinguish drug induced sinusoidal obstruction syndrome from the graft-vs-host syndrome that would require change in the immunosuppressive regimen. Similarly, in situations where the implicated medication is considered necessary or life supporting, liver biopsy may be helpful in making a decision about the likelihood of drug induced liver injury. Examples of situations in which liver biopsy can be extremely helpful diagnostically include acetaminophen as a cause of acute liver injury and methotrexate or amiodarone as a cause of apparent chronic liver disease. In most situations, however, a liver biopsy is largely supportive of the diagnosis and not absolutely essential in patient management.


New and Updated

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...