Table 108Odds ratios (95% CrI) from conventional (white area) and network metaanalysis (grey area) for the number of people experiencing at least one exacerbation with short-term (4–10 weeks) treatment

PlaceboAztreonam lysineTobramycin (nebulised)Tobramycin + Fosfomycin (nebulised)
Placebo0.3
(0.08, 0.92)
3
(0.55, 24.66)
0.9
(0.25, 3.81)
Aztreonam lysine0.3
(0.08, 0.92)
Tobramycin (nebulised)3
(0.55, 24.66)
10.43
(1.31, 122.2)
Tobramycin + Fosfomycin (nebulised)0.9
(0.25, 3.81)
3.11
(0.55, 21.38)
0.3
(0.03, 2.78)

Results in the top right diagonal of the table are the mean differences and 95% CrI from the conventional meta-analyses of direct evidence between the column-defined treatments compared to the row-defined treatment. Mean differences greater than 0 favour the column-defined treatment.

Results in the bottom left are the mean differences and 95% CrI from the NMA model of direct and indirect evidence between the row-defined treatments compared to the column-defined treatments. Mean differences greater than 0 favour the row-defined treatment.

Numbers in bold denote results for which the 95% CrI does not include the null effect of 0

From: 9, Pulmonary monitoring, assessment and management

Cover of Cystic Fibrosis
Cystic Fibrosis: Diagnosis and management.
NICE Guideline, No. 78.
National Guideline Alliance (UK).
Copyright © NICE 2017.

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