Table 94Summary of included studies for the antimicrobial treatment of infection with or exacerbation due B Cepacia Complex (BCC)

StudyIntervention/ComparisonPopulationOutcomesComments
Cochrane systematic reviews
Horsley 2016
Cochrane SR		Intervention
Any antibiotic treatment regimen for treating an exacerbation of CF lung disease
Comparison
  • Placebo
  • Different antibiotic regimen
Patients with cystic fibrosis of any age with evidence of pulmonary infection with organisms of the BCC (defined as at least 2 positive sputum or bronchoalveolar lavage specimens within the last 6 monthsNo studies were identified for inclusion in this reviewAMSTAR score:11/1 1
Regan 2016
Cochrane SR		Intervention
Any antibiotic or antibiotic adjuvant therapy used alone or in combination to eradicate BCC infection
Comparison
  • Placebo
  • No treatment
  • Alternative antimicrobial agent (excluding the participant’s usual therapeutic regimen)
Any person of any age with a confirmed clinical diagnosis of cystic fibrosis who acquires a new infection or a re-infection with BCC. People will all disease severity were included.No studies were identified for inclusion in this reviewAMSTAR score:10/11

BCC: B Cepacia Complex; CYSTIS FIBROSIS: cystic fibrosis; SR: systematic review

From: 9, Pulmonary monitoring, assessment and management

Cover of Cystic Fibrosis
Cystic Fibrosis: Diagnosis and management.
NICE Guideline, No. 78.
National Guideline Alliance (UK).
Copyright © NICE 2017.

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