Table 52Studies included in the model according to strategy and pathogen

StudyPathogenClinical evidence review comparison
Cohorts by pathogen
Federiksen 1999Chronic PA & Intermittent PAComparison 6. Cohort segregation versus no cohort segregation (inpatient and outpatient)
France 2008aIntermittent BCCComparison 6. Cohort segregation versus no cohort segregation (inpatient and outpatient)
Hoiby 1989bChronic PAComparison 6. Cohort segregation versus no cohort segregation (inpatient and outpatient)
Lee 2004Chronic PA & Intermittent PAComparison 2. Cohort segregation by location versus no cohort segregation (outpatient)
Whitford 1995Intermittent BCCComparison 6. Cohort segregation versus no cohort segregation (inpatient and outpatient)
Protective equipment
Chen 2001aIntermittent BCCComparison 10. Cohort segregation + individual segregation + protective equipment versus usual care (inpatient and outpatient)
Savant 2014Intermittent PAComparison 3. Combination of protective equipment + individual segregation versus incomplete protective equipment + incomplete individual segregatione (outpatient)
Single inpatient room versus ward bed
Chen 2001aIntermittent BCCComparison 9. Cohort segregation + individual segregation versus cohort segregation (inpatient and outpatient)
France 2008aIntermittent BCCComparison 7. Complete cohort segregation versus incomplete cohort segregation (inpatient and outpatient)
Incomplete cohort segregation including en suite bathroom facilities versus no cohort segregation
Jones 2005Superinfection with chronic PAc & Intermittent PAdComparison 6. Cohort segregation versus no cohort segregation (inpatient and outpatient)

BCC, B cepacia complex; PA, P aeruginosa

(a)

Intermittent assumed as chronic not reported

(b)

Multiply resistant pseudomonas assumed to have a similar treatment cost and effect on quality of life as chronic pseudomonas

(c)

Incidence of superinfection by transmissible strains among people with cystic fibrosis already infected with chronic P aeruginosa

(d)

New cases of P aeruginosa infection with transmissible strain among people with cystic fibrosis without chronic P aeruginosa infection assumed to have a similar treatment cost and effect on quality of life as intermittent P aeruginosa

(e)

Individual segregation achieved through a “no-waiting” room policy incurring no additional cost to incomplete segregation

From: Appendix K, Health Economics

Cover of Cystic Fibrosis
Cystic Fibrosis: Diagnosis and management.
NICE Guideline, No. 78.
National Guideline Alliance (UK).
Copyright © NICE 2017.

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