TABLE 3.1Heat shock protein families

FamilyMembers/other namesPhysiological functionPathological involvement
HSP10HSP10, HSP17Promotes substrate
Release with HSP60		unknown
Small HSPHSP20, HSP23
HSP27, HSP28		F-actin assembly, Molecular chaperones.unknown
HSP40HSP32, HSP40,
HSP47		Guides protein folding, Binding and transport of collagenAtherosclerosis
HSP60HSP58, GroEL
HSP60, HSP65
Grp58		Assemble polypeptides;
Translocate proteins across membranes;
Accelerate protein folding and unfolding		Atherosclerosis, Rheumatoid arthritis, Adjuvant arthritis, Diabetes mellitus, Systemic sclerosis.
HSP70HSP68, Dnak.
Hsc70, Hsx70
HSP72, HSP73
HSP75, Grp75
HSP78, Grp78		Molecular chaperone:
Assembly and transport newly synthesized proteins;
Fold or unfold polypeptides;
Remove denatured proteins;
Bind to specific polypeptides (e.g., p53);
ATPase activity.		Atherosclerosis
Tuberculosis, Leprosy, Filariasis,
HSP90HSP83, HptG
HSP87, HSP90-α
grp94, HSP90-β		Bind to specific polypeptide receptors (e.g., glucocorticoid receptor).Schistosomiasis, Systemic lupus erythematosus.

From: 3, Atherosclerosis

Cover of Mechanisms of Vascular Disease
Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists [Internet].
Fitridge R, Thompson M, editors.
Adelaide (AU): University of Adelaide Press; 2011.
© The Contributors 2011.

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