Table 10, Cochrane Collaboration use of clinical heterogeneity in key questions - Comparative Effectiveness Review Methods: Clinical Heterogeneity

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Condition and Citation	Demographic Variables	Disease Variables (DV), Risk Factors (RF), Coexisting Conditions (CC), Cointerventions (CI)	Were population subgroups pre-identified? If so, how?
Breast cancer⁵⁷^,⁵⁸	No	No	NA
Lung cancer⁵⁹^,⁶¹	No	No	NA
Cadona Zorilla et al., 2008⁶⁰	No	DV	No
Prostate cancer⁶²^,⁶³	No	No	NA

Cesarean delivery⁶⁵^,⁶⁶	No	No	NA
Chronic kidney disease⁶⁷	No	CI	No
Roderick et al., 2007⁶⁸	No	No	NA
COPD^69–71	No	No	NA
Yang et al., 2007⁷²	No	DV	No
Depression^73–77	No	No	NA
Heart failure⁶⁴	Age	No	No
Heavy Menstrual Bleeding^78–81	No	No	NA
Hypertension⁸⁵^,⁸⁶	No	No	NA
Wiysonge et al., 2007⁸²	Age, race/ethnicity	No	No
Hodson et al., 2007⁸³	Age	DV	No
Abalos et al., 2007⁸⁴	Sex	DV, CC	No
Evans et al., 2007⁸⁷	Age	No	No
Labor induction⁸⁸	No	DV	No
Boulvain et al., 2008⁸⁹	No	No	NA
Myocardial infarction¹⁶^,¹⁸^,⁹⁰	No	No	NA
Osteoarthritis¹⁴^,⁹¹^,⁹²	No	DV	No

: No indicates that the report did not consider the variable for the key questions.
: NA indicates that the variable was not applicable because key questions did not address subgroups.

Comparative Effectiveness Review Methods: Clinical Heterogeneity [Internet].

West SL, Gartlehner G, Mansfield AJ, et al.

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