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Cooley PC, Clark RF, Folsom RE. Assessing Gene-Environment Interactions in Genome-Wide Association Studies: Statistical Approaches [Internet]. Research Triangle Park (NC): RTI Press; 2014 May. doi: 10.3768/rtipress.2014.rr.0022.1405
| Φ | Π | Additive | Dominant | Recessive | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| M-1 | M-2 | M-3 | M-1 | M-2 | M-3 | M-1 | M-2 | M-3 | ||
| 1.10 | 1.00 | .002 | .000 | .004 | .000 | .006 | .004 | .000 | .000 | .000 |
| 1.10 | 1.05 | .002 | .008 | .006 | .000 | .014 | .014 | .000 | .000 | .000 |
| 1.10 | 1.10 | .002 | .034 | .030 | .000 | .044 | .030 | .004 | .004 | .000 |
| 1.10 | 1.15 | .002 | .152 | .096 | .000 | .190 | .120 | .062 | .024 | .018 |
| 1.10 | 1.20 | .004 | .472 | .296 | .000 | .500 | .260 | .258 | .228 | .066 |
| 1.15 | 1.00 | .024 | .036 | .042 | .000 | .034 | .024 | .000 | .000 | .000 |
| 1.15 | 1.05 | .030 | .068 | .058 | .000 | .048 | .052 | .000 | .000 | .000 |
| 1.15 | 1.10 | .040 | .152 | .106 | .000 | .162 | .118 | .002 | .002 | .002 |
| 1.15 | 1.15 | .046 | .390 | .278 | .000 | .384 | .302 | .048 | .034 | .012 |
| 1.15 | 1.20 | .052 | .650 | .524 | .000 | .670 | .508 | .308 | .278 | .074 |
| 1.20 | 1.00 | .246 | .174 | .206 | .004 | .114 | .104 | .000 | .000 | .000 |
| 1.20 | 1.05 | .270 | .274 | .250 | .002 | .166 | .150 | .000 | .000 | .000 |
| 1.20 | 1.10 | .286 | .402 | .376 | .002 | .344 | .260 | .004 | .002 | .002 |
| 1.20 | 1.15 | .348 | .658 | .548 | .012 | .520 | .490 | .098 | .058 | .032 |
| 1.20 | 1.20 | .378 | .862 | .718 | .024 | .796 | .660 | .299 | .289 | .107 |
Φ = genetic inheritance (GI) risk level; Π = environmental exposure (EE) risk level.
Note: Bold indicates the optimal model. The statistical models (M-1, M-2, and M-3) are described in Table 4.
From: Assessing Gene-Environment Interactions in Genome-Wide Association Studies: Statistical Approaches
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