Table 5, Strengths and Limitations of Randomized Controlled Trials using Downs and Black - e-Therapy Interventions for the Treatments of Substance Use Disorders and Other Addictions: A Review of Clinical Effectiveness

Strengths	Limitations
Luquiens¹⁷
randomized controlled trial hypothesis clearly described method of selection from source population and representation described loss to follow-up reported main outcomes, interventions, patient characteristics, and main findings clearly described estimates of random variability and actual probability values provided power calculation to detect a clinically important effect performed	patient and assessor not blinded to patient treatment assignment.
Schaub¹⁸
randomized controlled trial hypothesis clearly described method of selection from source population and representation described loss to follow-up reported main outcomes, interventions, patient characteristics, and main findings clearly described power calculation to detect a clinically important effect performed estimates of random variability and actual probability values provided	patient and assessor not blinded to patient treatment assignment.

From: e-Therapy Interventions for the Treatments of Substance Use Disorders and Other Addictions: A Review of Clinical Effectiveness

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e-Therapy Interventions for the Treatments of Substance Use Disorders and Other Addictions: A Review of Clinical Effectiveness [Internet].

Ho C, Severn M.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Jun 27.

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Table 5Strengths and Limitations of Randomized Controlled Trials using Downs and Black14

Table 5Strengths and Limitations of Randomized Controlled Trials using Downs and Black¹⁴