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Calcium Entry Channels in Non-Excitable Cells
Editors: Juliusz Ashot Kozak and James W. Putney, Jr.
Boca Raton (FL): CRC Press/Taylor & Francis; 2018.
ISBN-13: 9781498752725 (hardback)ISBN-13: 9781315152592 (ebook)
Contents
- Series Preface
- Preface
- 1. Electrophysiological Methods for Recording CRAC and TRPV5/6 ChannelsJ. Ashot Kozak and Grigori Rychkov.
- 2. Studies of Structure-Function and Subunit Composition of Orai/STIM ChannelMarc Fahrner, Rainer Schindl, and Christoph Romanin.
- 3. Signaling ER Store Depletion to Plasma Membrane Orai ChannelsAparna Gudlur and Patrick Hogan.
- 4. Modulation of Orai1 and STIM1 by Cellular FactorsJin Seok Woo, Sonal Srikanth, and Yousang Gwack.
- 4.1. Introduction
- 4.2. Modulators of Orai1 via Protein Interaction
- 4.3. Vesicular Components in Regulation of Orai1
- 4.4. Store-Independent Regulation of Orai1 via Protein Interaction
- 4.5. STIM1-Interacting Molecules at the ER-PM Junctions
- 4.6. Modulators of STIM1 Function
- 4.7. STIM1 as a Regulator for Non-CRAC Channel-Related Functions
- 4.8. Methods Used to Identify Interacting Partners of Orai1 and STIM1
- 4.9. Conclusions and Perspectives
- Acknowledgments
- References
- 5. CRAC Channels and Ca2+-Dependent Gene ExpressionYi-Chun Yeh and Anant B. Parekh.
- 5.1. Introduction
- 5.2. Ca2+ Entry through CRAC Channels Activates Gene Expression
- 5.3. The Importance of Ca2+ Microdomains near Open CRAC Channels in the Regulation of Transcription
- 5.4. How Local Is Local?
- 5.5. Sensing Local Ca2+ near CRAC Channels
- 5.6. Parallel Processing of the CRAC Channel Ca2+ Microdomain
- 5.7. Caveolin-1 Differentially Regulates NFAT and c-Fos Activities
- 5.8. Modular Regulation by Caveolin-1
- 5.9. Large Bulk Ca2+ Rises and c-Fos Gene Expression
- 5.10. Conclusion
- References
- 6. Function of Orai/Stim Proteins Studied in Transgenic Animal ModelsMasatsugu Oh-Hora and Xiuyuan Lu.
- 6.1. Introduction
- 6.2. Strategies for Gene Targeting
- 6.3. Establishment of Orai/Stim-Deficient Mice at the Whole-Body Level
- 6.4. Establishment of Tissue-Specific Orai/Stim-Deficient Mouse Lines
- 6.5. Methods to Establish Murine Embryonic Fibroblast Lines from KO Mice
- 6.6. Function of Orai/Stim Proteins in the Immune System
- 6.7. Function of Orai/Stim Proteins in the Muscle
- 6.8. Function of Orai/Stim Proteins in the Nervous System
- 6.9. Concluding Remarks
- Acknowledgments
- References
- 7. Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET ApproachesYandong Zhou, Youjun Wang, and Donald L. Gill.
- 8. Optogenetic Approaches to Control Calcium Entry in Non-Excitable CellsLian He, Qian Zhang, Yubin Zhou, and Yun Huang.
- 9. Regulation of Orai/STIM Channels by pHAlbert S. Yu, Zhichao Yue, Jianlin Feng, and Lixia Yue.
- 10. Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ SignalingKlaus Groschner, Niroj Shrestha, and Nicola Fameli.
- 11. Store-Independent Orai Channels Regulated by STIMXuexin Zhang, Maxime Gueguinou, and Mohamed Trebak.
- 12. Regulation and Role of Store-Operated Ca2+ Entry in Cellular ProliferationRawad Hodeify, Fang Yu, Raphael Courjaret, Nancy Nader, Maya Dib, Lu Sun, Ethel Adap, Satanay Hubrack, and Khaled Machaca.
- 13. TRPV5 and TRPV6 Calcium-Selective ChannelsJi-Bin Peng, Yoshiro Suzuki, Gergely Gyimesi, and Matthias A. Hediger.
- 13.1. Introduction
- 13.2. Ca2+ Transport across Epithelia
- 13.3. Identification of TRPV5 and TRPV6 by Expression Cloning
- 13.4. Ca2+ Transport Properties Uncovered by Various Approaches
- 13.5. Physiological Roles Revealed Using Genetically Engineered Animal Models
- 13.6. Proteins that Regulate TRPV5 and TRPV6
- 13.7. Potential Use of TRPV6 in Therapy and Development of Chemical Modulators
- 13.8. TRPV5 and TRPV6 Mutations and Kidney Stone Diseases
- 13.9. Concluding Remarks
- Acknowledgments
- References
- 14. Determining the Crystal Structure of TRPV6Kei Saotome, Appu K. Singh, and Alexander I. Sobolevsky.
- 14.1. Introduction
- 14.2. Precrystallization Screening of Protein Expression and Biochemical Behavior Using FSEC
- 14.3. Large-Scale Purification and Crystallization
- 14.4. Collection and Processing of Diffraction Data
- 14.5. Protein Engineering to Improve Crystal Packing
- 14.6. Comparison of TRPV6 and Orai Structures
- Acknowledgments
- References
- 15. Identifying TRP Channel Subunit Stoichiometry Using Combined Single Channel Single Molecule Determinations (SC-SMD)Laura G. Ceballos, Alexander Asanov, and Luis Vaca.
- 16. Pharmacology of Store-Operated Calcium Entry ChannelsGary S. Bird and James W. Putney, Jr.
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Names: Kozak, Juliusz Ashot, editor. | Putney, James W., Jr., editor.
Title: Calcium entry channels in non-excitable cells / [edited by] Juliusz
Ashot Kozak and James W. Putney, Jr.
Other titles: Methods in signal transduction.
Description: Boca Raton : Taylor & Francis, 2017. | Series: Methods in signal transduction series | Includes bibliographical references and index.
Identifiers: LCCN 2016053681 | ISBN 9781498752725 (hardback : alk. paper)
Subjects: | MESH: Calcium Channels--physiology | Calcium Signaling--physiology
Classification: LCC QP552.C24 | NLM QU 55.7 | DDC 572/.696--dc23
LC record available at https://lccn.loc.gov/2016053681
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