Table 1:

Selection Criteria

PopulationWomen with early stage, human epidermal growth factor receptor 2 [HER2] negative, lymph node negative, estrogen-receptor [ER] positive and/or progesterone receptor [PR] positive breast cancer
InterventionGene expression/profiling tests:
Oncotype DX (by Genomic Health)
EndoPredict (by Myriad Genetics)
MammaPrint (by Agendia)
Prosigna (by NanoString)
Mammostrat (by Clarient Diagnostic Services)
ComparatorQ1-2:
Gene expression/profiling tests:
  • Oncotype DX (by Genomic Health)
  • EndoPredict (by Myriad Genetics)
  • MammaPrint (by Agendia)
  • Prosigna (by NanoString)
  • Mammostrat (by Clarient Diagnostic Services)
OutcomesQ1: Clinical utility (predicting who should receive adjunct chemotherapy and/or evaluate cancer recurrence)
Q2: Cost-effectiveness
Study DesignsHeath technology assessments (HTA), systematic reviews (SR), meta-analyses (MA), randomized control trials (RCT), non-RCTs, and economic evaluations

From: Gene Expression Tests for Women with Early Stage Breast Cancer: A Review of Clinical Utility and Cost-Effectiveness

Cover of Gene Expression Tests for Women with Early Stage Breast Cancer: A Review of Clinical Utility and Cost-Effectiveness
Gene Expression Tests for Women with Early Stage Breast Cancer: A Review of Clinical Utility and Cost-Effectiveness [Internet].
Narain T, Adcock L.
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