| CID | Target Name | IC50/EC50 (nM) [SID, AID] | Anti-target Name(s) | IC50/EC50 (μM) [SID, AID] | Selectivity | Secondary Assay(s) Name: IC50/EC50 (nM) [SID, AID] |
|---|---|---|---|---|---|---|
| CID5310346 ML146 | NOD1 | 1536 nM IC50 SID-87225488, AID-2333 & AID-2466 | NOD2 TNFα HEK293 cytotoxicity | 12.66 μM IC50
SID-87225488, AID-2334
& AID-2475 44.61 μM IC50 SID87225488 AID-2337& AID-2483 >20 μM IC50 SID-87225488, AID-2335 & AID-2469 | > 8- fold Vs NOD2 >29- fold vs TNFα | NOD1 mediated IL-8 secretion: Assay provider’s 3430 nM
IC50
SID-87225488, AID-2505 NOD2 mediated IL-8 secretion: Assay provider’s >25,000 nM IC50 SID-87225488, AID-2503 TNFα mediated IL-8 secretion: Assay provider’s >25,000 nM IC50 SID-87225488, AID-2504 NF-κB selectivity γ-tri-DAP: Assay provider 14,430 nM IC50 SID-87225488, AID-2793 NF-κB selectivity DOX: Assay provider >25000 nM IC50 SID-87225488, AID-2789 NF-κB selectivity PMA/Iono: Assay Provider >25000 nM IC50 SID-87225488, AID-2792 |
From: High Throughput Screening Assays for NOD1 Inhibitors - Probe 2
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