Table 9NF-kB Activation Pathway Selectivity of Probe and analogs

Compound IDEC50 (µM)
CIDMLS-#DAPDoxPMA/Ionomycin
531034601232514.5 ± 1.8>25>25
5389756008596>25>25>25
647508018316>25>25>25
6662670041838.7 ± 0.75.9 ± 0.63.5 ± 0.3
81460734231718.5 ± 2.8>25>25
653676013818>25>2517.8 ± 4.8
5761203013615>25>25>25

From: High Throughput Screening Assays for NOD1 Inhibitors - Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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