Table 8Comparative data for probe specificity

CIDSIDMLS-#
Image ml146fu42.jpg
Inhibitory activity of compound on IL-8 Secretion Stimulated* by:
γ-tri-DAP NOD1 ligandMDP- NOD2 ligandTNFα
R1R2R3IC50 (µM)IC50 (µM)IC50 (µM)
5310346872254880012325
Image ml146fu43.jpg
Image ml146fu44.jpg
H3.43**
647508875447960018316
Image ml146fu45.jpg
Image ml146fu46.jpg
H4.10**
814607875447990342317
Image ml146fu47.jpg
Image ml146fu48.jpg
H3.31**
*

For the IL-8 Secretion assays all compounds were tested at 0.25, 1.0, 2.5, 5.0, 10 & 25 µM. unless otherwise noted the IC50 > than the highest concentration tested (25 µM). Where IC50 values are listed, they are fitted by a 4-parameter fit using PRISM software

From: High Throughput Screening Assays for NOD1 Inhibitors - Probe 2

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Probe Reports from the NIH Molecular Libraries Program [Internet].
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