CIDTarget NameIC50/EC50 (nM) [SID, AID]Anti- target Name(s)IC50/EC50 (μM) [SID, AID]SelectivitySecondary Assay(s) Name: IC50/EC50 (nM) [SID, AID]
CID5236771 (bisamides)

ML139		KOR κ-opioid receptor120 nM IC50 SID-87218782 AID-2284MOR μ-opioid receptor

DOR δ-opioid receptor		>32 μM EC50 SID-87218782 AID-2352

>32 μM EC50 SID-87218782 AID-2370		> 270X (Dx/HCS) >530X (HCS/HCS)

> 270X (Dx/HCS) >530X (HCS/HCS)		KOR Transflour <60 nM EC50 [SID-87218782, AID-2359]

MOR Transflour >32,000 nM EC50 [SID-87218782, AID-2352]

DOR Transflour >32,000 nM EC50 [SID-87218782, AID-2370]
44601470 (triazoles)

ML138		KOR κ-opioid receptor870 nM IC50 SID-87334039 AID-2284MOR μ-opioid receptor

DOR δ-opioid receptor		>32 μM EC50 SID-87334039 AID-2352

>32 μM EC50 SID-87334039 AID-2370		> 37X (Dx/HCS) >91X (HCS/HCS)

> 37X (Dx/HCS) >91X (HCS/HCS)		KOR Transfluor 350 nM EC50 [SID-87334039, AID-2359]

MOR Transfluor >32000 nM EC50 [SID-87334039, AID-2352]

DOR Transfluor >32000 nM EC50 [SID-87334039, AID-2370]

From: Selective KOP Receptor Agonists: Probe 1 & Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].
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