Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI) - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf

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Table 6Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI)

Receptor	Probe K_i (nM)
Receptor		ML139	ML138
5ht1a
5ht1b
5ht1d
5ht1e
5ht2a
5ht2b		1,237
5ht2c
5ht3
5ht5a		4,986
5ht6
5ht7
Alpha1A
Alpha1B
Alpha1D
Alpha2A		5,525
Alpha2B		9,601
Alpha2C
Beta1
Beta2
Beta3		7,312
BZP Rat Brain Site
D1		1,796
D2
D3
D4
D5		7018
DAT
DOR	1,315	484.1
H1
H2
H3
H4
KOR	0.79	0.23
M1
M2
M3
M4
M5
MOR	671.1	773.3
NET
SERT
Sigma 1

: Green: K_i > 10,000 or 1^ary screen missed
: Orange: 2^ndary assay pending

From: Selective KOP Receptor Agonists: Probe 1 & Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program

Probe Reports from the NIH Molecular Libraries Program [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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