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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 6Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI)
| Receptor | Probe Ki (nM) | |
|---|---|---|
| ML139 | ML138 | |
| 5ht1a | ||
| 5ht1b | ||
| 5ht1d | ||
| 5ht1e | ||
| 5ht2a | ||
| 5ht2b | 1,237 | |
| 5ht2c | ||
| 5ht3 | ||
| 5ht5a | 4,986 | |
| 5ht6 | ||
| 5ht7 | ||
| Alpha1A | ||
| Alpha1B | ||
| Alpha1D | ||
| Alpha2A | 5,525 | |
| Alpha2B | 9,601 | |
| Alpha2C | ||
| Beta1 | ||
| Beta2 | ||
| Beta3 | 7,312 | |
| BZP Rat Brain Site | ||
| D1 | 1,796 | |
| D2 | ||
| D3 | ||
| D4 | ||
| D5 | 7018 | |
| DAT | ||
| DOR | 1,315 | 484.1 |
| H1 | ||
| H2 | ||
| H3 | ||
| H4 | ||
| KOR | 0.79 | 0.23 |
| M1 | ||
| M2 | ||
| M3 | ||
| M4 | ||
| M5 | ||
| MOR | 671.1 | 773.3 |
| NET | ||
| SERT | ||
| Sigma 1 | ||
Green: Ki > 10,000 or 1ary screen missed
Orange: 2ndary assay pending
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