NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 6Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI)
| Receptor | Probe Ki (nM) | |
|---|---|---|
| ML139 | ML138 | |
| 5ht1a | ||
| 5ht1b | ||
| 5ht1d | ||
| 5ht1e | ||
| 5ht2a | ||
| 5ht2b | 1,237 | |
| 5ht2c | ||
| 5ht3 | ||
| 5ht5a | 4,986 | |
| 5ht6 | ||
| 5ht7 | ||
| Alpha1A | ||
| Alpha1B | ||
| Alpha1D | ||
| Alpha2A | 5,525 | |
| Alpha2B | 9,601 | |
| Alpha2C | ||
| Beta1 | ||
| Beta2 | ||
| Beta3 | 7,312 | |
| BZP Rat Brain Site | ||
| D1 | 1,796 | |
| D2 | ||
| D3 | ||
| D4 | ||
| D5 | 7018 | |
| DAT | ||
| DOR | 1,315 | 484.1 |
| H1 | ||
| H2 | ||
| H3 | ||
| H4 | ||
| KOR | 0.79 | 0.23 |
| M1 | ||
| M2 | ||
| M3 | ||
| M4 | ||
| M5 | ||
| MOR | 671.1 | 773.3 |
| NET | ||
| SERT | ||
| Sigma 1 | ||
Green: Ki > 10,000 or 1ary screen missed
Orange: 2ndary assay pending
- Review Antagonist for the Kappa Opioid Receptor.[Probe Reports from the NIH Mol...]Review Antagonist for the Kappa Opioid Receptor.Hedrick MP, Gosalia P, Li K, Frankowski KJ, Shi S, Prisinzano TE, Schoenen F, Aubé J, Su Y, Stonich D, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Review Selective KOP Receptor Antagonists: Probe 1.[Probe Reports from the NIH Mol...]Review Selective KOP Receptor Antagonists: Probe 1.Hedrick MP, Gosalia P, Frankowski K, Whipple DA, Shi S, Prisinzano TE, Schoenen F, Aubé J, Su Y, Vasile S, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.[Neuropharmacology. 2015]Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Neuropharmacology. 2015 Dec; 99:131-41. Epub 2015 Jul 6.
- Opioid receptor involvement in food deprivation-induced feeding: evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats.[J Pharmacol Exp Ther. 2004]Opioid receptor involvement in food deprivation-induced feeding: evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats.Hadjimarkou MM, Singh A, Kandov Y, Israel Y, Pan YX, Rossi GC, Pasternak GW, Bodnar RJ. J Pharmacol Exp Ther. 2004 Dec; 311(3):1188-202. Epub 2004 Aug 27.
- NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.[Peptides. 2005]NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats.Israel Y, Kandov Y, Khaimova E, Kest A, Lewis SR, Pasternak GW, Pan YX, Rossi GC, Bodnar RJ. Peptides. 2005 Jul; 26(7):1167-75. Epub 2005 Feb 26.
- Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138...Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI) - Probe Reports from the NIH Molecular Libraries Program
Your browsing activity is empty.
Activity recording is turned off.
See more...