Table 6Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI)
Receptor | Probe Ki (nM) | |
---|---|---|
ML139 | ML138 | |
5ht1a | ||
5ht1b | ||
5ht1d | ||
5ht1e | ||
5ht2a | ||
5ht2b | 1,237 | |
5ht2c | ||
5ht3 | ||
5ht5a | 4,986 | |
5ht6 | ||
5ht7 | ||
Alpha1A | ||
Alpha1B | ||
Alpha1D | ||
Alpha2A | 5,525 | |
Alpha2B | 9,601 | |
Alpha2C | ||
Beta1 | ||
Beta2 | ||
Beta3 | 7,312 | |
BZP Rat Brain Site | ||
D1 | 1,796 | |
D2 | ||
D3 | ||
D4 | ||
D5 | 7018 | |
DAT | ||
DOR | 1,315 | 484.1 |
H1 | ||
H2 | ||
H3 | ||
H4 | ||
KOR | 0.79 | 0.23 |
M1 | ||
M2 | ||
M3 | ||
M4 | ||
M5 | ||
MOR | 671.1 | 773.3 |
NET | ||
SERT | ||
Sigma 1 |
Green: Ki > 10,000 or 1ary screen missed
Orange: 2ndary assay pending
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- Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138...Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI) - Probe Reports from the NIH Molecular Libraries Program
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