| Author Year Condition Quality | Drug, dosage Number of subjects Duration | Results |
|---|---|---|
| Cetirizine compared with fexofenadine | ||
| Handa 200475 Fair | Cetirizine 10 mg qd Fexofenadine 180 mg qd 116 4 weeks | Cetirizine vs. fexofenadine Symptom-free at endpoint: 51.9% vs. 4.4% Partial improvement at endpoint: 36.5% vs. 42.2% No improvement at endpoint: 11.5% vs. 53.3% P=NR |
| Cetirizine compared with levocetirizine | ||
| Garg 200773 Fair | Cetirizine 10 mg Levocetirizine 5 mg 30 6 weeks | Cetirizine vs. levocetirizine (N) Wheal response 30 vs. 28 Flare response 30 vs. 30 Itch response 30 vs. 9 |
| Cetirizine compared with loratadine | ||
| Guerra et al 199474 Fair | Cetirizine 10 mg Loratadine 10 mg Placebo 116 4 weeks | Significant (P<0.01) loratadine vs. cetirizine on days 3, 14, 28 (NS on day 7) Day 3/7/14/28: Loratadine: −23%/ −46%/ −65%/ −81% Cetirizine: −35%/ −50%/ −60%/ −69% Placebo: −19%/ −23%/ −34%/ −55% Response rate (symptom-free): Loratadine 63% vs. cetirizine 45%; NSD Placebo 13% |
| Thomas 199877 Fair | Cetirizine 10 mg Loratadine 10 mg 202 4 weeks | Data reported in graphs Loratadine vs. cetirizine The number, size, and the duration of lesions (P<0.05) Fall in the mean score of pruritus (P<0.05) |
| Levocetirizine compared with desloratadine | ||
| Potter 200976 Fair | Levocetirizine 5 mg Desloratadine 5 mg 886 4 weeks | Levocetirizine vs. desloratadine Pruritus severity score First treatment week 1.02 (0.04) vs. 1.18 (0.04); P<0.001 Entire treatment period 0.86 (0.04) vs. 0.99 (0.04); P=0.004 Chronic idiopathic urticaria composite score First treatment week 1.98 (0.08) vs. 2.23 (0.08); P=0.005 Entire treatment period 1.71 (0.07) vs. 1.88 (0.07); P=0.041 |
Abbreviations: NR, not reported; NS, not significant; NSD, no significant difference; qd, once daily.
From: Results
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