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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 95233-18-4
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of atovaquone during breastfeeding. However, the quantity of drug in breast milk is assumed too low to provide adequate protection against malaria for the breastfed infant.[1] A dosage has been established for infants weighing as little as 5 kg, so it is unlikely to adversely affect breastfed infants weighing 5 kg or more.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
- Centers for Disease Control and Prevention. Malaria. In, CDC Yellow Book 2024: Health Information for International Travel. New York: Oxford University Press 2024. https://wwwnc
.cdc.gov /travel/yellowbook/2024 /infections-diseases /malaria#treatment.
Substance Identification
Substance Name
Atovaquone
CAS Registry Number
95233-18-4
Drug Class
Breast Feeding
Milk, Human
Anti-infective Agents
Antiparasitic Agents
Antimalarials
Antiprotozoal Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Atovaquone and Proguanil.[Drugs and Lactation Database (...]Review Atovaquone and Proguanil.. Drugs and Lactation Database (LactMed®). 2006
- Atovaquone oral bioavailability enhancement using electrospraying technology.[Eur J Pharm Sci. 2018]Atovaquone oral bioavailability enhancement using electrospraying technology.Darade A, Pathak S, Sharma S, Patravale V. Eur J Pharm Sci. 2018 Jan 1; 111:195-204. Epub 2017 Sep 30.
- Review Tecovirimat.[Drugs and Lactation Database (...]Review Tecovirimat.. Drugs and Lactation Database (LactMed®). 2006
- Review Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.[Am J Trop Med Hyg. 1999]Review Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB. Am J Trop Med Hyg. 1999 Apr; 60(4):533-41.
- Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80).[Biochem Pharmacol. 1992]Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80).Fry M, Pudney M. Biochem Pharmacol. 1992 Apr 1; 43(7):1545-53.
- Atovaquone - Drugs and Lactation Database (LactMed®)Atovaquone - Drugs and Lactation Database (LactMed®)
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