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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 156879-69-5
Drug Levels and Effects
Summary of Use during Lactation
No information is available on the use of atovaquone and proguanil during breastfeeding. The Centers for Disease Control and Prevention does not currently recommend it for the prevention of malaria in women breastfeeding infants weighing less than 5 kg (11 pounds). However, it can be used for treatment of women who are breastfeeding infants of any weight when the potential benefit outweighs the potential risk to the infant (e.g., treating a breastfeeding woman who has acquired P. falciparum malaria in an area of multidrug-resistant strains and who cannot tolerate other treatment options).[1]
In general, very small amounts of antimalarial drugs are excreted in the breast milk of lactating women. Because the quantity of antimalarial drugs transferred in breast milk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must also receive the recommended dosages of antimalarial drugs.[1]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Centers for Disease Control and Prevention. CDC Yellow Book 2020: Health Information for International Travel. New York: Oxford University Press 2019. https://wwwnc
.cdc.gov /travel/yellowbook/2020 /travel-related-infectious-diseases /malaria.
Substance Identification
Substance Name
Atovaquone and Proguanil
CAS Registry Number
156879-69-5
Drug Class
Breast Feeding
Anti-infective Agents
Antiparasitic Agents
Antimalarials
Antiprotozoal Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.[Am J Trop Med Hyg. 1999]Review Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB. Am J Trop Med Hyg. 1999 Apr; 60(4):533-41.
- Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.[Clin Infect Dis. 2002]Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.Ling J, Baird JK, Fryauff DJ, Sismadi P, Bangs MJ, Lacy M, Barcus MJ, Gramzinski R, Maguire JD, Kumusumangsih M, et al. Clin Infect Dis. 2002 Oct 1; 35(7):825-33. Epub 2002 Sep 11.
- Review Atovaquone.[Drugs and Lactation Database (...]Review Atovaquone.. Drugs and Lactation Database (LactMed®). 2006
- Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children.[Pediatr Infect Dis J. 1999]Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children.Anabwani G, Canfield CJ, Hutchinson DB. Pediatr Infect Dis J. 1999 May; 18(5):456-61.
- Atovaquone + proguanil: new preparation. Second-line antimalarial combination.[Prescrire Int. 2002]Atovaquone + proguanil: new preparation. Second-line antimalarial combination.. Prescrire Int. 2002 Oct; 11(61):131-6.
- Atovaquone and Proguanil - Drugs and Lactation Database (LactMed®)Atovaquone and Proguanil - Drugs and Lactation Database (LactMed®)
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