Table 4.

AMP PGx (2018) CYP2C19 Tier 2 Variant Alleles.

GenotypeAllele functional status*Defining functional variant*Multiethnic allele frequency, %
CYP2C19*4 No functionrs283995040.1-0.3
CYP2C19*4B No functionrs28399504; rs122485600-0.2
CYP2C19*5 No functionrs563370130
CYP2C19*6 No functionrs725522670-0.1
CYP2C19*7 No functionrs725581860
CYP2C19*8 No functionrs412915560.1-0.3
CYP2C19*9 Decreased functionrs178847120.1-4.2
CYP2C19*10 Decreased functionrs64134380.1-6
CYP2C19*35 No functionrs127692050.8-3.1
*

Multiethnic allele frequency from PharmVar​.org (last accessed June 20, 2017.)

Both Table 3 and Table 4 are adapted from (26).

From: Brivaracetam Therapy and CYP2C19 Genotype

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Medical Genetics Summaries [Internet].
Pratt VM, Scott SA, Pirmohamed M, et al., editors.
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