Table 5.Genetic and related effects of aldicarb

Test systemResultaDoseb
LED/HID		Reference
Without exogenous metabolic systemWith exogenous metabolic system
SAD, Salmonella typhimwium TA1538/1978, differential toxicity+01000.0000Rashid & Mumma (1986)
ERD, Escherichia coli WP2, differential toxicity−02000.0000Rashid & Mumma (1986)
ERD, Escherichia coli K12, differential toxicity−02000.0000Rashid & Mumma (1986)
SA0, Salmonella typhimurium TA100, reverse mutation−−5000.0000Dunkel et al. (1985)
SA0, Salmonella typhimurium TA100 reverse mutation−−5000.0000Zeiger et al. (1988)
SA5, Salmonella typhimurium TA1535, reverse mutation−−5000.0000Dunkel et al. (1985)
SA5, Salmonella typhimurium TA1535, reverse mutation−−5000.0000Zeiger et al. (1988)
SA7, Salmonella typhimurium TA1537, reverse mutation−−5000.0000Dunkel et al. (1985)
SA7, Salmonella typhimurium TA1537, reverse mutation−−5000.0000Zeiger et al. (1988)
SA8, Salmonella typhimurium TA1538, reverse mutation−−5000.0000Dunkel et al. (1985)
SA9, Salmonella typhimurium TA98, reverse mutation−−5000.0000Dunkel et al. (1985)
SA9, Salmonella typhimurium TA98 reverse mutation−−5000.0000Zeiger et al. (1988)
SAS, Salmonella typhimurium TA97, reverse mutation−−5000.0000Zeiger et al. (1988)
ECW, Escherichia coli WP2 uvrA, reverse mutation−−5000.0000Dunkel et al. (1985)
G5T, Gene mutation, mouse lymphoma L5178Y cells, tk locus+02600.0000Caspary et al. (1988)
G5T, Gene mutation, mouse lymphoma L5178Y cells, tk locus++1300.0000Mitchell et al. (1988)
G5T, Gene mutation, mouse lymphoma L5178Y cells, tk locus−+1000.0000Myhr & Caspary (1988)
DIH, DNA strand breakage, human skin fibroblasts in vitro−0      1.9000Blevins et al. (1977)
GIH, Gene mutation, human lymphoblastoid TK6 cells, tk locus+01600.0000Caspary et al. (1988)
SHL, Sister chromatid exchange, human lymphocytes in vitro++      0.0000Debuyst & Van Larebeke (1983; abstract)
SHL, Sister chromatid exchange, human lymphocytes in vitro(+)+    40.0000Cid & Matos (1984)
CHL, Chromosomal aberrations, human lymphocytes in vitro(+)+  350.0000Cid & Matos (1987)
CBA, Chromosomal aberrations, rat bone-marrow in vivo+0      0.0012 × 5 i.p.Sharaf et al. (1982)
a

+ , positive; (+), weak positive; −, negative; 0, not tested

b

In-vitro tests, µg/ml; in-vivo tests, mg/kg bw

From: Aldicarb

Cover of Occupational Exposures in Insecticide Application, and Some Pesticides
Occupational Exposures in Insecticide Application, and Some Pesticides.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 53.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
©International Agency for Research on Cancer, 1991.

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