| Type of exposure/population studied | No. of cases | Clinical symptom reporteda | Estimated dose | Other endpoints/ comments | Reference |
|---|---|---|---|---|---|
| Foreman running mechanical bagging machine for one day | 1 | + | NRb | Decrease in plasma and red blood cell AChEc | US Environmental Protection Agency (1975) |
| California, USA, 1974–76 Acute occupational intoxication as reported by physicians; dermal and inhalation exposure | 38 | + | NR | Not reported | Peoples et al. (1978) |
| Florida, USA, 1981 Interview survey of 436 citrus growers | 1 | + | NR | Intoxication confirmed by unspecified laboratory tests | Griffith & Duncan (1985) |
| Farm worker exposed ~2 h without adequate protection | 1 | − | 0.275 mg/kg bw | Incapacitation due to intoxication thought to contribute to death in an accident | Lee & Ransdell (1984) |
| Woman ate leaf of spearmint growing near roses sprayed three weeks previously | 1 | + | NR | NR | Marshall (1985) |
| Nebraska, USA 1977 and 1978 Two incidents of intoxication following ingestion of cucumbers; aldicarb conta- mination identified in later incident | 14 | + | (0.025–0.041 mg/kg bw)d | No abnormal blood chemistry | Goes et al. (1980) |
| Vancouver, Canada, 1985 Ingestion of cucumbers contaminated with aldicarb | 140 | + | 0.01–0.03 mg/kg bw | NR | Hirsch et al. (1987) |
| Oregon and California, USA Ingestion of watermelon | |||||
| Oregon, aldicarb residues in 10/16 melons eaten by definite cases | 61 definite, 43 suspected 264 reported | + | NR | Green et al. (1987) | |
| California, aldicarb sulfoxide residues in 10/250 melons | 690 probable of 1350 reported | + | 0.002–0.06 mg/kg bw | NR | Jackson & Goldman (1986); Jackson et al. (1986) |
| Suffolk County, NY, USA, 1981 Questionnaire survey of 1500 households with well-water aldicarb levels > 7 ppb (µg/l) | 641 individuals evaluated from 204 question- naires | − | NR | Trend in neurological syndromes reported with increasing aldicarb con- centration | Sterman & Varma (1983) |
| Portage County, WI, USA, 1985 37 women from households supplied by well-water screened for aldicarb and 13 from households supplied with muni- cipal water | 23 exposed to detectable levels of aldicarb, 27 controls | − | 0.3–48 µg/day | Increased number of T8 cells; increased% of total lymphocytes as T8 cells; decreased ratio T4:T8 cells in exposed versus controls | Fiore et al. (1986) |
Clinical symptoms reported consistent with inhibition of acetylcholinesterase, + ; no such symptom reported, -
NR, none reported and no details given to estimate dose
AChE, acetylcholinesterase
Dose estimated by Jackson & Goldman (1986)
From: Aldicarb
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