TABLE E4-14Studies of DE-71 and Attention in Rats

StudySpeciesLife Stage ExposedObservation TimeTestNOAEL (mg/kg-day)LOAEL (mg/kg-day)
Driscoll et al. 2009Long-Evans ratsLifetime*PND 40-95Visual task4.5None
Long-Evans ratsLifetime*PND 40-95Attention task I34.5
Long-Evans ratsLifetime*PND 40-95Attention task II4.5None
Driscoll et al. 2012Long-Evans ratsPND 6-12PND 40-95Attention task15None
Long-Evans ratsPND 6-12PND 40-95Visual task15None
Dufault et al. 2005Long-Evans ratsPND 6-12PND 30Attention task30None
*

Animals were exposed throughout gestation via treated dams and via chow after weaning.

NOTE: GD, gestation day; LOAEL, lowest-observed-adverse-effect level; NOAEL, no-observed-adverse-effect level; PND, postnatal day.

From: Appendix E, Supporting Materials for the PBDE (Animal) Systematic Review

Cover of Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals
Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals.
National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee on Endocrine-Related Low-Dose Toxicity.
Washington (DC): National Academies Press (US); 2017 Jul 18.
Copyright 2017 by the National Academy of Sciences. All rights reserved.

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