TABLE E4-13Studies of DE-71 and Memory in Rats

StudySpeciesLife Stage ExposedObservation TimeTestNOAEL (mg/kg-day)LOAEL (mg/kg-day)
Bowers et al. 2015Sprague-Dawley ratsGD 1 - PND 21PND 235Morris water maze30None
de-Miranda et al. 2016Wistar rats (female)PND 5-22PND 100Radial mazeNone30
Wistar rats (male)PND 5-22PND 100Radial maze30None

NOTE: GD, gestation day; LOAEL, lowest-observed-adverse-effect level; NOAEL, no-observed-adverse-effect level; PND, postnatal day.

From: Appendix E, Supporting Materials for the PBDE (Animal) Systematic Review

Cover of Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals
Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals.
National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee on Endocrine-Related Low-Dose Toxicity.
Washington (DC): National Academies Press (US); 2017 Jul 18.
Copyright 2017 by the National Academy of Sciences. All rights reserved.

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