Table 55.2.

Examples of alkaloids that inhibit glycosidases involved in N-linked glycan biosynthesis

AlkaloidSourceTarget
Australine Image ch55t2a.jpg α-glucosidase I
Castanospermine Image ch55t2b.jpg α-glucosidase I and II
Deoxynojirimycin Image ch55t2c.jpg α-glucosidase II (and I)
Deoxymannojirimycin Image ch55t2d.jpg α-mannosidase I
Kifunensin Image ch55t2e.jpg α-mannosidase I
Swainsonine Image ch55t2f.jpg α-mannosidase II
Mannostatin A Image ch55t2g.jpg α-mannosidase II

From: Chapter 55, Chemical Tools for Inhibiting Glycosylation

Cover of Essentials of Glycobiology
Essentials of Glycobiology [Internet]. 3rd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017.
Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.

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