Table 9, CDR’s Estimated Weighted Average Cost of Brivaracetam Versus Comparators Using Manufacturer’s Dose Distribution (Dispensing Fees and Markup Removed) - Brivaracetam (Brivlera)

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Table 9CDR’s Estimated Weighted Average Cost of Brivaracetam Versus Comparators Using Manufacturer’s Dose Distribution (Dispensing Fees and Markup Removed)

Treatment	Unit Dose (mg)	Unit Cost^a	Daily Dosage (mg)	Cost per Day^a	Patient Distribution^b	Weighted Average Cost per Day	Weighted Average Cost per 365 Days	Incremental Cost of Brivaracetam
Brivaracetam	10	$4.32	20.0	$8.64	0.0%	$0.00
	25	$4.32	50.0	$8.64	25.0%	$2.16
	50	$4.32	100.0	$8.64	25.0%	$2.16
	75	$4.32	150.0	$8.64	25.0%	$2.16
	100	$4.32	200.0	$8.64	25.0%	$2.16
	Weighted total for brivaracetam					$8.64	$3,153.60	Reference
Lacosamide	50	$2.53	100.0	$5.05	0.0%	$0.00
	100	$3.50	200.0	$7.00	33.3%	$2.33
	150	$4.71	300.0	$9.41	33.3%	$3.14
	200	$5.80	400.0	$11.60	33.3%	$3.87
	Weighted total for lacosamide					$9.34	$3,407.88	−$254.28
Perampanel	2	$9.45	2.0	$9.45	0.0%	$0.00
	4	$9.45	4.0	$9.45	20.0%	$1.89
	6	$9.45	6.0	$9.45	20.0%	$1.89
	8	$9.45	8.0	$9.45	20.0%	$1.89
	10	$9.45	10.0	$9.45	20.0%	$1.89
	12	$9.45	12.0	$9.45	20.0%	$1.89
	Weighted total for perampanel					$9.45	$3,449.25	−$295.65
Eslicarbazepine	200	$9.56	200.0	$9.56	0.0%	$0.00
	400	$9.56	400.0	$9.56	33.3%	$3.19
	600	$9.56	600.0	$9.56	33.3%	$3.19
	800	$9.56	800.0	$9.56	33.3%	$3.19
	Weighted total for eslicarbazepine					$9.56	$3,489.40	−$335.80

: CDR = CADTH Common Drug Review.
a: Comparator unit prices are ODB list prices, accessed July 2016. Unit cost for brivaracetam provided by manufacturer.
b: Manufacturer assumed equal distribution across recommended maintenance doses.

From: APPENDIX 2, REVIEWER WORKSHEETS

Brivaracetam (Brivlera) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Feb.

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