| Reporting Strategy | PRISMA | NR | Cochrane methodology, NICE recommendation, PRISMA | NR |
| Sources of Information | MEDLINE, In-Process & Other Non-Indexed Citation, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science, and Scopus Manual searching based on bibliographies of included trials and systematic reviews Conference abstracts
| MEDLINE, Embase, Cochrane Central Register of Controlled Trials Manual searching based on bibliographies of a technical report from the American Gastroenterology Association and Cochrane Database of Systematic Reviews Conference abstracts
| MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Database of Abstracts of Reviews of Effectiveness Manual searching based on bibliographies of included trials and systematic reviews Clinical trial registries (e.g., clinicaltrials.gov, World Health Organization’s International Clinical Trials Registry)
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| Search Dates | Database search between January 1, 1985, and September 30, 2013 Relevant conference abstracts search between 2005 and 2013
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| Search Terms Strategy | No language restrictions with controlled vocabulary for RCTs of biologic therapies in patients with IBD | Controlled vocabulary for RCTs of biologic and immunosuppressant therapies in patients with CD | No language restrictions with controlled vocabulary for CD trials | Controlled vocabulary for RCTs of biologic therapies in patients with CD published in English |
| Screening | Two investigators screened the trials identified in the systematic literature search, first by the titles and abstracts, and then followed by the full texts. Disagreements between investigators were settled by consultation between the investigators and a third investigator.
| Two investigators screened the trials identified in the systematic literature search, first by the titles and abstracts, and then followed by the full texts. Any disagreements between investigators were settled by consensus.
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| Quality Assessment | Two investigators independently rated the quality of the included studies based on the criteria established by the Evidence-Based Gastroenterology Steering Group, which considers concealed random allocation, patient and caregiver blinding, interventions between treatment arms, follow-up, and ITT analysis. | Qualitative assessment was conducted on each of the included studies based on the Cochrane Risk of Bias tool. | Qualitative assessment was conducted on each of the included studies based on the assessment criteria recommended by NICE. | One investigator rated the quality of the included studies based on the criteria established by Evidence-Based Gastroenterology Steering Group, which considers concealed random allocation, patient and caregiver blinding, interventions between treatment arms, follow-up, and ITT analysis. |
