TABLE 26

Summary of performance of SNP and TC scores in non-BRCA1 + set, alone and when combined

IQR (controls)OR95% CIAUC95% CILR-CHI2
SNP RR0.77–1.291.531.26 to 1.870.580.54 to 0.6218.4
TC 10-year2.29–5.681.571.30 to 1.910.590.55 to 0.6322.8
TC + SNP 10-year2.17–5.821.741.45 to 2.090.620.58 to 0.6637.7

AUC, area under the curve.

From: Chapter 3, Project 2: assessment of predictive value of new genetic variants

Cover of Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study
Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study.
Programme Grants for Applied Research, No. 4.11.
Evans DG, Astley S, Stavrinos P, et al.
Southampton (UK): NIHR Journals Library; 2016 Aug.
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