TABLE 19

Descriptive statistics of the population

GeneCarrierBreast cancerNumber of carriers
BRCA1IndexYes211
No44
First-degree relativeYes52
No125
Second-degree relativeYes7
No11
Third-degree relativeYes0
No7
Fourth-degree relativeYes0
No1
Fifth-degree relativeYes1
No1
BRCA2IndexYes200
No33
First-degree relativeYes69
No118
Second-degree relativeYes5
No10
Third-degree relativeYes8
No2
Fourth-degree relativeYes0
No0
Fifth-degree relativeYes0
No0

Source: reproduced with permission from Ingham SL, Warwick J, Byers H, Lalloo F, Newman WG, Evans DGR. Is multiple SNP testing in BRCA2 and BRCA1 female carriers ready for use in clinical practice? Results from a large Genetic Centre in the UK. Clinical Genetics 2013, 84:1, 37–42, © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.140

From: Chapter 3, Project 2: assessment of predictive value of new genetic variants

Cover of Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study
Improvement in risk prediction, early detection and prevention of breast cancer in the NHS Breast Screening Programme and family history clinics: a dual cohort study.
Programme Grants for Applied Research, No. 4.11.
Evans DG, Astley S, Stavrinos P, et al.
Southampton (UK): NIHR Journals Library; 2016 Aug.
Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Evans et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

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