Table 33, Adverse effects in case series of surgical treatments for IH - Diagnosis and Management of Infantile Hemangioma

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Intervention	Harm/Adverse Event	Number of Studies (# Participants With Harm/Total Participants)	Reported Rates Across Studies
Surgery including excision and resection	Dehiscences²³⁸^,²⁴⁰^,²⁴⁶^,²⁴⁸^,²⁵¹	5 (17/357)	1.4%–5.5%
	Postoperative traumatic wound dehiscence ²³⁸^,²⁴¹^,²⁴³	3 (3/119)	2.3%–2.8%
	Wound infections minor or dehiscence²⁴¹	1 (6/44)	13.6%
	Postoperative infection²⁴⁰^,²⁴⁹	2 (1/264)	0–2%
	Postoperative hematoma²⁴⁵	1 (1/67)	1.5%
	Intraoperative bleeding²⁴⁹	1 (2/50)	4%
	Skin necrosis ²⁴³^,²⁴⁵	2 (3/106)	2.6%–3%
	Hypertrophic scarring/cheloids ²⁴⁹^,²⁵¹	2 (10/142)	4%–9.8%
	Incomplete excision with scarring²⁴⁹	1 (1/50)	2%
	Facial paresis, transient postop²³⁹	1 (4/43)	9.3%
	Permanent palsy of facial nerve²³⁹	1 (1/43)	2.3%
	Hemorrhage and ulceration²⁴⁴	1 (3/127)	2.4%
	Hypopigmentation of the skin or vermillion of the lip²⁴⁴	1 (5/127)	3.9%
	Labial mucoceles observed 3 years post- surgery²⁴⁴	1 (3/127)	2.4%
	Alopecia/Loss of small eyelash segment²⁴²^,²⁵¹	2 (2/125)	1.1%–3%
	Cellulitis²⁵¹	1 (2/92)	2.2%
	Functional impairment²⁵¹	1 (2/92)	2.2%

Diagnosis and Management of Infantile Hemangioma [Internet].

Comparative Effectiveness Reviews, No. 168.

Chinnadurai S, Snyder K, Sathe N, et al.

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