Table 25Key resolution outcomes in studies comparing PDL and observation

Author, Year
Groups (n)
Quality		Age, Months

Type		LocationMethods and Measures of Resolution/ResponseResolution Outcomes
Kessels et al. 2013210

G1: Pulsed dye laser (11)
G2: Observation (11)

Quality: Good		Age, median (range)
G1: 3 (1.7–5.0)
G2: 3 (1.5–4.5)

Type
Superficial and cutaneous only		G1+G2: multiple
  • Photographs
  • Color measured by reflectance photometer
  • Improvement scale evaluated by blinded panel
    1= no improvement
    2= moderate improvement
    3 = significant improvement
Change in echo depth, median (interquartile range)
G1: −1.21 (−1.75 to 0.15)
G2: −1.10 (−2.00 to 0.96)
G1 vs.G2 p= 0.69

Change in surface, median (interquartile range)
G1: 0.40 (0.10 to 0.80)
G2: 0.00 (−0.08 to 0.40)
G1 vs.G2 p= 0.08

Color change, median (interquartile range)
G1: 10.16 (5.50 to 15.41)
G2: 4.23 (0.84 to 5.28)
G1 vs.G2 p= 0.03
Batta et al. 2002212

G1: Pulsed dye laser (60)
G2: Observation (61)

Quality: Fair		Age, median (range, days
G1: 38 (10 to 101)
G2: 32 (5 to 79)

Type, n (%)
Flat
G1: 31 (52)
G2: 30 (49)
Raised
G1: 29 (48)
G2: 31 (51)		G1+G2: multiple
  • Photographs
  • Primary outcome measure assessed by investigator: complete clearance or minimum residual signs at age 1 year
  • Blinded medical observer assessed redness (secondary outcome measure)
Complete clearance or minimum residual signs, n (%)
G1: 25 (42)
G2: 27 (44)
G1 vs.G2: p=0.92

Complete only
G1: 18 (30)
G2: 3 (5)
G1 vs.G2: p=0.001

G = group; n = number; PDL = pulsed dye laser

From: Results

Cover of Diagnosis and Management of Infantile Hemangioma
Diagnosis and Management of Infantile Hemangioma [Internet].
Comparative Effectiveness Reviews, No. 168.
Chinnadurai S, Snyder K, Sathe N, et al.
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