| Outcomes | No. of Participants (studies) Follow up | Quality of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
|---|---|---|---|---|---|
| Risk with placebo - low risk - adults | Risk difference with TXA (95% CI) | ||||
| No. of patients receiving allogeneic transfusions (route) | 626 (4 studies) | VERY LOWa,b due to risk of bias, imprecision | RR 0.83 (0.3 to 2.29) | Study population | |
| 23 per 1000 | 4 fewer per 1000 (from 16 fewer to 29 more) | ||||
| No. of patients receiving allogeneic transfusions (route) - Topical TXA | 400 (1 study) | VERY LOWa,b due to risk of bias, imprecision | RR 0.2 (0.01 to 4.14) | Study population | |
| 10 per 1000 | 8 fewer per 1000 (from 10 fewer to 31 more) | ||||
| No. of patients receiving allogeneic transfusions (route) - Oral TXA | 136 (1 study) | VERY LOWa,b due to risk of bias, imprecision | RR 1.13 (0.36 to 3.53) | Study population | |
| 76 per 1000 | 10 more per 1000 (from 48 fewer to 192 more) | ||||
| Blood loss (type of surgery-topical TXA)) -Orthognathic surgery | 0 (1 study) | MODERATEa due to risk of bias | The mean blood loss (type of surgery-topical TXA) -orthognathic surgery in the intervention groups was 0.93 higher (0.73 to 1.2 higher) | ||
| Blood loss (type of surgery-topical TXA) - otolaryngeal surgery | 0 (2 studies) | The mean blood loss (type of surgery-topical TXA) - otolaryngeal surgery in the intervention groups was 0.74 higher (0.73 to 0.76 higher) | |||
Majority of the evidence was at high risk of bias.
Confidence interval crosses both MIDs.
From: 6, Alternatives to blood transfusion for patients having surgery: Cell salvage and tranexamic acid
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