Table I-5Pharmacologic agents considered for DBD review

Drug Class
Individual agent (proprietary name)
Alpha-agonists
  • Clonidine
  • Guanfacine (Intuniv®)
First-generation antipsychotics
  • Chlorpromazine
  • Fluphenazine
  • Haloperidol
  • Loxapine
  • Perphenazine
  • Prochlorperazine
  • Thiothixene
  • Thioridazine
  • Trifluoperazine
Selective serotonin reuptake inhibitors (SSRI)
  • Fluoxetine
  • Sertraline
  • Citalopram
  • Escitalopram
  • Paroxetine
  • Fluvoxamine
Anticonvulsants
  • Carbamazepine (Tegretol®)
  • Oxcarbazepine (Trileptal®)
  • Divalproex sodium (Depakote®)
  • Lamotrigine (Lamictal®)
  • Valproate/ Valproic acid
Beta-blockers
  • Propranolol
  • Metoprolol
  • Pindolol
  • Nadolol
Second-generation (atypical) antipsychotics
  • Aripiprazole (Abilify®)
  • Asenapine (Saphris®)
  • Clozapine (Clozaril®)
  • Iloperidone (Fanapt®)
  • Lurasidone (Latuda®)
  • Olanzapine (Zyprexa®)
  • Olanzapine/Fluoxetine (Symbyax®)
  • Paliperidone (Invega®)
  • Quetiapine (Seroquel®)
  • Risperidone (Risperdal®)
  • Ziprasidone (Geodon®)
Other (e.g., antihistamines, benzodiazepines, mood stabilizers, non-SSRI antidepressants)
  • Lithium
  • Atomoxetine (Strattera®)
  • Naltrexone
  • Hydroxyzine
  • Clonazepam (Klonopin®)
  • Levetiracetam (Keppra®)
  • Lorazepam (Ativan®)
  • Bupropion
Central nervous system (CNS) stimulants
  • Amphetamine-Dextroamphetamine (Adderall®)
  • Methylphenidate (Ritalin®)
  • Lisdexamfetamine (Vyvanse®)

From: Appendix I, Pharmacologic Approval Status, Harms, and Indications

Cover of Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents
Psychosocial and Pharmacologic Interventions for Disruptive Behavior in Children and Adolescents [Internet].
Comparative Effectiveness Reviews, No. 154.
Epstein R, Fonnesbeck C, Williamson E, et al.
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