Table BDefinitions of the grades of overall strength of evidence

GradeDefinition
HighHigh confidence that the evidence reflects the true effect. Further research is very unlikely to change our confidence in the estimate of effect.
ModerateModerate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of the effect and may change the estimate.
LowLow confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of the effect and is likely to change the estimate.
InsufficientEvidence either is unavailable or does not permit estimation of an effect.

From: Executive Summary

Cover of Medication Therapy Management Interventions in Outpatient Settings
Medication Therapy Management Interventions in Outpatient Settings [Internet].
Comparative Effectiveness Reviews, No. 138.
Viswanathan M, Kahwati LC, Golin CE, et al.

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