Table 9-11Accuracy of 12 symptoms and signs in the diagnosis of primary hypothyroidism 122 .

sensitivity
(%)		specificity
(%)		 positive predictive value (%) negative predictive value (%) score if present
Symptoms
•impairment of hearing
•diminished sweating
•constipation
•paraesthesia
•hoarseness
•weight increase
•dry skin		22
54
48
52
34
54
76		98
86
85
83
88
78
64		90
80
76
75
73
71
68		53
65
62
63
57
63
73		1
1
1
1
1
1
1
Physical signs
•slow movements
•periorbital puffiness
•delayed ankle reflex
•coarse skin
•cold skin
36
60
77
60
50
99
96
94
81
80
97
94
92
76
71
61
71
80
67
62
1
1
1
1
1
Sum of all symptoms and signs present† 12§

From: Adult Hypothyroidism

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