Table 5-1, Agents Inhibiting Thyroid Hormone Synthesis and Secretion - Endotext

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Table 5-1Agents Inhibiting Thyroid Hormone Synthesis and Secretion

Block iodide transport into the thyroid gland
Substance	Common Use
Monovalent anions (SCN^-, Cl0₄^-, N0₃^-)^a	Not in current use; Cl0₄^- test agent
Complex anions (monofluorosulfonate,difluorophosphate, fluoroborate)^a	-------
Minerals (bromine, fluorine)	In diet
Lithium^a	Treatment of manic-depressive psychosis
Ethionamide	Antituberculosis drug
Impair TG iodination and iodotyrosine coupling
Substance	Common Use
Thionamides and thiourylenes, (PTU,methimazole, carbimazole)^a	Antithyroid drugs
Sulfonamides (acetazolamide, sulfadiazine, sulfisoxazole)^a	Diuretic, bacteriostatic
Sulfonylureas (carbutamide, tolbutamide, metahexamide, ?chloropropamide)^a	Hypoglycemic agents
Salicylamides (p-aminosalicylic acid, p-aminobenzoic acid)^a	Antituberculosis drugs
Resorcinol	Cutaneous antiseptic
Amphenone	Anticonvulsive
Aminoglutethimide	Antiadrenal agent
Thiocyanate^a	No current use; in diet
Antipyrine (phenazone)^a	Antiasthmatic
Aminotriazole	"Cranberry poison”
Amphenidone	Tranquilizer
2,3-Dimercaptopropanol (BAL)	Chelating agent
Ketoconozole	Antifungal agent
Inhibitors of thyroid hormone secretion
Substance	Common Use
Amiodarone ^a	Antianginal and antiarrhythmic agent
Iodide (in large doses)^a	Antiseptic, expectorant, and others
Lithium^a	Treatment of manic-depressive psychosis
Cause Thryoiditis
Substance	Common Use
Amiodarone ^a	Antianginal and antiarrhythmic agent
Interleukin II ^a	Cancer therapy
g-Interferon ^a	Antiviral and cancer therapy
Sunitinib ^a	Cancer therapy
Sorafenib ^a	Cancer therapy
Ipilmumab ^a	Cancer therapy
Pembrolizumab ^a	Cancer therapy
Nivolumab ^a	Cancer therapy
Mechanism unknown
Substance	Common Use
p-bromdylamine maleate ^a	Antihistamine
Phenylbutazone ^a	Antiinflammatory agent
Minerals (calcium, rubidium, cobalt)^a	-------
Thalidomide³⁹⁶	Cancer therapy
^aReferences given in the text

From: Effects of the Environment, Chemicals and Drugs on Thyroid Function

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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