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Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
| Block iodide transport into the thyroid gland | |
| Substance | Common Use |
| Monovalent anions (SCN-, Cl04-, N03-)a | Not in current use; Cl04- test agent |
| Complex anions (monofluorosulfonate,difluorophosphate, fluoroborate)a | ------- |
| Minerals (bromine, fluorine) | In diet |
| Lithiuma | Treatment of manic-depressive psychosis |
| Ethionamide | Antituberculosis drug |
| Impair TG iodination and iodotyrosine coupling | |
| Substance | Common Use |
| Thionamides and thiourylenes, (PTU,methimazole, carbimazole)a | Antithyroid drugs |
| Sulfonamides (acetazolamide, sulfadiazine, sulfisoxazole)a | Diuretic, bacteriostatic |
| Sulfonylureas (carbutamide, tolbutamide, metahexamide, ?chloropropamide)a | Hypoglycemic agents |
| Salicylamides (p-aminosalicylic acid, p-aminobenzoic acid)a | Antituberculosis drugs |
| Resorcinol | Cutaneous antiseptic |
| Amphenone | Anticonvulsive |
| Aminoglutethimide | Antiadrenal agent |
| Thiocyanatea | No current use; in diet |
| Antipyrine (phenazone)a | Antiasthmatic |
| Aminotriazole | "Cranberry poison” |
| Amphenidone | Tranquilizer |
| 2,3-Dimercaptopropanol (BAL) | Chelating agent |
| Ketoconozole | Antifungal agent |
| Inhibitors of thyroid hormone secretion | |
| Substance | Common Use |
| Amiodarone a | Antianginal and antiarrhythmic agent |
| Iodide (in large doses)a | Antiseptic, expectorant, and others |
| Lithiuma | Treatment of manic-depressive psychosis |
| Cause Thryoiditis | |
| Substance | Common Use |
| Amiodarone a | Antianginal and antiarrhythmic agent |
| Interleukin II a | Cancer therapy |
| g-Interferon a | Antiviral and cancer therapy |
| Sunitinib a | Cancer therapy |
| Sorafenib a | Cancer therapy |
| Ipilmumab a | Cancer therapy |
| Pembrolizumab a | Cancer therapy |
| Nivolumab a | Cancer therapy |
| Mechanism unknown | |
| Substance | Common Use |
| p-bromdylamine maleate a | Antihistamine |
| Phenylbutazone a | Antiinflammatory agent |
| Minerals (calcium, rubidium, cobalt)a | ------- |
| Thalidomide396 | Cancer therapy |
| aReferences given in the text |
From: Effects of the Environment, Chemicals and Drugs on Thyroid Function
This electronic version has been made freely available under a Creative Commons (CC-BY-NC-ND) license. A copy of the license can be viewed at http://creativecommons.org/licenses/by-nc-nd/2.0/.
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